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Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis

Date Time
Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical models reversed these effects and reduced metastases, suggesting an important new therapeutic target for the deadly cancer.
“To our knowledge, this is the first study to show how these two major genetic drivers work together to promote tumor growth and metastasis,” Kim said. “We learned that signaling downstream of mutant KRAS directly promotes mutant p53 activity. This discovery provides not only a new therapeutic target but unveils a vast transcriptional network that is activated downstream of these mutant proteins.” ....

United States , Bingbing Dai , Gigi Lozano , Amandar Wasylishen , Jithesh Augustine , Jasonb Fleming , Yaan Kang , Timothyp Heffernan , Florencia Mcallister , Michael Kim , Christopher Bristow , Kendra Allton , Shunbin Xiong , Jenying Deng , Eugene Koay , Yun Zhang , Tarag Hughes , Michellec Barton , Guillermina Lozano , Christian Siangco , Xinqun Li , Anirban Maitra , Sheikh Ahmed Bin Zayed Al Nahyan Center , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Rose Cole Charitable Pria Foundation ,

Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis

Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Bingbing Dai , Gigi Lozano , Amandar Wasylishen , Jithesh Augustine , Jasonb Fleming , Yaan Kang , Timothyp Heffernan , Florencia Mcallister , Michael Kim , Christopher Bristow , Kendra Allton , Shunbin Xiong , Jenying Deng , Eugene Koay , Yun Zhang , Tarag Hughes , Michellec Barton , Guillermina Lozano , Christian Siangco , Xinqun Li , Anirban Maitra , Sheikh Ahmed Bin Zayed Al Nahyan Center , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Rose Cole Charitable Pria Foundation ,