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Frontiers | Preexposure and Postexposure Prophylaxis of Rabies With Adeno-Associated Virus Expressing Virus-Neutralizing Antibody in Rodent Models

Rabies, a fatal disease in humans and other mammals, is caused by the rabies virus (RABV), and it poses a public health threat in many parts of the world. Once symptoms of rabies appear, the mortality is near 100%. There is currently no effective treatment for rabies. In our study, two human-derived RABV-neutralizing antibodies (RVNA), CR57 and CR4098, were cloned into adeno-associated virus (AAV) vectors, and recombinant AAVs expressing RVNA were evaluated for postexposure prophylaxis after intrathecal injection into RABV-infected rats. At 4 days post-infection with a lethal dose of RABV, 60% of the rats that received an intrathecal injection of AAV-CR57 survived, while 100% of the rats inoculated with AAV-EGFP succumbed to rabies. Overall, these results demonstrate that AAV-encoding RVNA can be utilized as a potential human rabies postexposure prophylaxis. ....

South Korea , United States , Gang Cao , Rota Nodari , Ramos Silva , Luminometer Promega , Fujirebio Malvern , Luc Rabv Teluc , Graphpad Software Inc , National Natural Science Foundation Of China , Nancy Laboratory For Rabies , Drug Administration , Different Administration Ways , World Health Organization , Huazhong Agricultural University , Administration In Animals , Scientific Ethics Committee Of Huazhong Agricultural University , Ge Healthcare , Disease Control , Hubei Province , Scientific Ethics Committee , Huazhong Agricultural , Smart Lifesciences , Amersham Imager , Nancy Laboratory , Luc Luciferase ,

Antibacterial effects of Disulfiram in Helicobacter pylori

Confirmation of Gene Mutation
For all 12
H. pylori strains used, the sequence of 16SrDNA, a ribosomal gene involved in protein production, was analyzed, and the presence or absence of gene mutation was examined. Table 3 shows the number of base substitutions and the number of deletions/insertions in the 16SrDNA sequence. Of these, susceptible strain 3 (S3), amoxicillin-resistant strain 1 (AC1), amoxicillin-resistant strain 2 (AC2), clarithromycin-resistant strain 1 (CH1), and metronidazole-resistant strain 2 (MZ2) were resistant to disulfiram in the growth suppression test. Strains resistant to disulfiram tended to have fewer base deletions/insertions.
Table 3 16S rDNA Sequence
Discussion
Eradication therapy using amoxicillin and clarithromycin is performed for ....

Eteläuomen Läi , Okayama University Ethics Committee Number , Okayama University Hospital , Santa Cruz Biotechnology Inc , Hokkaido System Science Co Ltd , Okayama University Ethics Committee , Growth Inhibition Test , Santa Cruz Biotechnology , Western Blotting Substrate , Thermo Fisher Scientific , Amersham Imager , Nuclei Lysis Solution , Chain Reaction Detection , Kara Ex Taq , Applied Biosystems , Pathogenic Protein Expression Level , ஒக்யமா பல்கலைக்கழகம் மருத்துவமனை , சாந்தா குரூஸ் உயிரி தொழில்நுட்பவியல் இன்க் , சாந்தா குரூஸ் உயிரி தொழில்நுட்பவியல் , தெர்மோ மீனவர் அறிவியல் , அமர்ஷாம் இமேஜர் , பயன்படுத்தப்பட்டது உயிர் அமைப்புகள் ,

[Full text] Nrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer

Microvessel Density is Increased in Human GC Tissues
To confirm the association between Nrf2/HO-1 and angiogenesis in GC, we also determined the microvessel density of these human GC samples. Consistently, the microvessel density was low in paracancerous tissues, but high in GC. Moreover, the microvessel density was low, moderate, and high in well-, moderately-, and poorly differentiated GC, respectively (Figure 8). Collectively, the Nrf2/HO-1 axis is likely to participate in the malignant process of GC by affecting angiogenesis.
Figure 8 The microvessel density increased in human GC. Immunohistological staining of CD34 was used to determine the microvessel density in paracancerous tissue, well-differentiated GC, and poorly differentiated GC. ( ....

United States , Borough Of Bedford , United Kingdom , Eteläuomen Läi , Matrigel Corning , I Omega Bio Tek , People Hospital Of Ningxia Medical University , Hospital Of Ningxia Medical University Yinchuan , Ethics Review Committee Of Ningxia Medical University , National Institutes Of Health , People Hospital Of Ningxia Medical University Yinchuan , Department Of Pathology , Ethics Committee , Media Cybernetics Inc , Ge Healthcare , Jinzijing Biomedical Technology Co Ltd , General Hospital , Ningxia Medical University , Affiliated People , Ningxia Medical , Biological Industries , Kibbutz Beit Haemek , Image Pro Plus , Media Cybernetics , Amersham Imager , Little Chalfont ,

[Full text] Calycosin induces gastric cancer cell apoptosis

13–15 Calycosin is a fat-soluble component in the dried root of
Astragalus membranaceus, which are organic compounds widely found in nature. Calycosin exerts various anti-tumor activities in vitro and in vivo,
16–18 but its mechanism of action in human GC cells is not clear.
In this study, we evaluated the effects of calycosin on apoptosis, the cell cycle, and migration of GC cells under ROS regulation. In addition, we also determined the roles of MAPK/STAT3/NF-κB pathways in these processes.
Materials and Methods
Cell Lines and Cell Culture
Twelve types of GC cells (AGS, KATO-3, MKN-28, MKN-45, NCI-N87, SNU-5, SNU-216, SNU-484, SNU-668, YCC-1, YCC-6, and YCC-16) and normal human lung cells IMR-90 were purchased from American Type Culture Collection (Manassas, VA, USA), and three normal cell lines (GES-1, L-02, and 293T) were purchased from Saiqi Biotech Co., Ltd (Shanghai, China). AGS, KATO-3, MKN-28, MKN-45, SNU-5, SNU-216, SNU-484, SNU-668, IMR-90, ....

Nordrhein Westfalen , United States , Franklin Lakes , Japan General , Becton Dickinson , Preparation Of Nuclear , Bio Inc , Biotek Instruments Inc , Beyotime Institute Biotechnology , Saiqi Biotech Co Ltd Shanghai , Pall Corp , Santa Cruz Biotechnology Inc , Nuclear Extraction Reagent , Beckman Coulter Inc , American Type Culture Collection , Modified Eagle Medium , Cell Counting , Biotek Instruments , Staining Kit , Annexinv Apoptosis Detection Kit , Mitochondrial Membrane Potential Assay Kit , Cell Imaging System , Thermo Fisher Scientific , Beckman Coulter , Cell Cycle , Quantitation Assay Kit ,