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UNSW researchers find novel way to attack the 'fortress' surrounding pancreatic tumors


UNSW researchers find novel way to attack the fortress surrounding pancreatic tumors
May 17 2021
Tackling the scar tissue that shields pancreatic tumors from effective drug access is a promising advance in a notoriously hard-to-treat cancer.
Dr George Sharbeen and Associate Professor Phoebe Phillips in their lab. Photo: Richard Freeman / UNSW
UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in ....

United States , Phoebe Phillips , Joshua Mccarroll , Cyrille Boyer , Richard Freeman , George Sharbeen , Cancer Research , American Association For Cancer Research , University Of Queensland Professor Thomas Davis , Children Cancer Institute , Medicine Health , Associate Professor Phoebe Phillips , American Association , Associate Professor , Queensland Professor Thomas Davis , Associate Professor Joshua Mccarroll , Cancer Institute , Clinical Trial , Pancreatic Cancer , ஒன்றுபட்டது மாநிலங்களில் , ஃபோப் பிலிப்ஸ் , சிரில் பையன் , ரிச்சர்ட் ஃப்ரீமேன் , புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , குழந்தைகள் புற்றுநோய் நிறுவனம் ,

Pancreatic Cancer May Succumb to "Dual Cell" Approach


Pancreatic Cancer May Succumb to “Dual Cell” Approach
Photo of a human pancreatic tumor section showing SLC7A11 in helper cells (yellow). [UNSW Sydney]
May 13, 2021
To fight pancreatic cancer more effectively, we should do more than attack cancer cells. We should also attack their collaborators, cancer-associated fibroblasts (CAFs). By widening the fight to encompass CAFs—cells that create fibrotic fortresses around pancreatic tumors—we may finally overcome a disease that has been known to withstand the most determined sieges.
The castle keep and outer walls of a pancreatic tumor were fired upon simultaneously in research conducted by scientists at the University of New South Wales (UNSW). The scientists’ weapon of choice? A drug that inhibits SLC7A11, a cystine transporter. ....

Phoebe Phillips , David Goldstein , Joshua Mccarroll , Cyrille Boyer , Thomas Davis , Cancer Research , University Of New South Wales , University Of Queensland , Children Cancer Institute , Medicine Health , New South Wales , ஃபோப் பிலிப்ஸ் , டேவிட் கோல்ட்ஸ்டைன் , சிரில் பையன் , தாமஸ் டேவிஸ் , புற்றுநோய் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் புதியது தெற்கு வேல்ஸ் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து , குழந்தைகள் புற்றுநோய் நிறுவனம் , மருந்து ஆரோக்கியம் , புதியது தெற்கு வேல்ஸ் ,

Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumours – India Education | Latest Education News India | Global Educational News


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UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in 
Cancer Research, a journal of the American Association for Cancer Research.
“Pancreatic cancer has seen minimal improvement in survival for the last four decades – and without immediate action, it is predicted to be the world’s second biggest cancer killer by 2025,” says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health. ....

New South Wales , United States , Phoebe Phillips , David Goldstein , Joshua Mccarroll , Cyrille Boyer , George Sharbeen , Australian Pancreatic Cancer Foundation , University Of Queensland Professor Thomas Davis , Cancer Institute , Cancer Research , Translational Program Grant , American Association For Cancer Research , Children Cancer Institute , Medicine Health , American Association , Associate Professor Phoebe Phillips , Queensland Professor Thomas Davis , Associate Professor Joshua Mccarroll , Professor David Goldstein , புதியது தெற்கு வேல்ஸ் , ஒன்றுபட்டது மாநிலங்களில் , ஃபோப் பிலிப்ஸ் , டேவிட் கோல்ட்ஸ்டைன் , சிரில் பையன் , ஆஸ்திரேலிய கணையம் புற்றுநோய் அடித்தளம் ,

Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumors


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Credit: UNSW Sydney
UNSW medical researchers have found a way to starve pancreatic cancer cells and disable the cells that block treatment from working effectively. Their findings in mice and human lab models - which have been 10 years in the making and are about to be put to the test in a human clinical trial - are published today in
Cancer Research, a journal of the American Association for Cancer Research.
Pancreatic cancer has seen minimal improvement in survival for the last four decades - and without immediate action, it is predicted to be the world s second biggest cancer killer by 2025, says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health. ....

United States , Phoebe Phillips , David Goldstein , Joshua Mccarroll , Cyrille Boyer , George Sharbeen , Australian Pancreatic Cancer Foundation , University Of Queensland Professor Thomas Davis , Cancer Institute , Cancer Research , Translational Program Grant , American Association For Cancer Research , Children Cancer Institute , Medicine Health , American Association , Associate Professor Phoebe Phillips , Queensland Professor Thomas Davis , Associate Professor Joshua Mccarroll , Professor David Goldstein , ஒன்றுபட்டது மாநிலங்களில் , ஃபோப் பிலிப்ஸ் , டேவிட் கோல்ட்ஸ்டைன் , சிரில் பையன் , ஆஸ்திரேலிய கணையம் புற்றுநோய் அடித்தளம் , புற்றுநோய் நிறுவனம் , புற்றுநோய் ஆராய்ச்சி ,