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UNSW researchers find novel way to attack the fortress surrounding pancreatic tumors May 17 2021 Tackling the scar tissue that shields pancreatic tumors from effective drug access is a promising advance in a notoriously hard-to-treat cancer. Dr George Sharbeen and Associate Professor Phoebe Phillips in their lab. Photo: Richard Freeman / UNSW UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in ....
Pancreatic Cancer May Succumb to âDual Cellâ Approach Photo of a human pancreatic tumor section showing SLC7A11 in helper cells (yellow). [UNSW Sydney] May 13, 2021 To fight pancreatic cancer more effectively, we should do more than attack cancer cells. We should also attack their collaborators, cancer-associated fibroblasts (CAFs). By widening the fight to encompass CAFsâcells that create fibrotic fortresses around pancreatic tumorsâwe may finally overcome a disease that has been known to withstand the most determined sieges. The castle keep and outer walls of a pancreatic tumor were fired upon simultaneously in research conducted by scientists at the University of New South Wales (UNSW). The scientistsâ weapon of choice? A drug that inhibits SLC7A11, a cystine transporter. ....
Tackling the scar tissue that shields pancreatic tumours from effective drug access is a promising advance in a notoriously hard-to-treat cancer. . ....
Share UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in Cancer Research, a journal of the American Association for Cancer Research. “Pancreatic cancer has seen minimal improvement in survival for the last four decades – and without immediate action, it is predicted to be the world’s second biggest cancer killer by 2025,” says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health. ....
E-Mail Credit: UNSW Sydney UNSW medical researchers have found a way to starve pancreatic cancer cells and disable the cells that block treatment from working effectively. Their findings in mice and human lab models - which have been 10 years in the making and are about to be put to the test in a human clinical trial - are published today in Cancer Research, a journal of the American Association for Cancer Research. Pancreatic cancer has seen minimal improvement in survival for the last four decades - and without immediate action, it is predicted to be the world s second biggest cancer killer by 2025, says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health. ....