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January 20, 2021
Biologists have long wondered how complex organisms contain a variety of dramatically different types of cells with specialized functions, even though all of those cells are genetically identical.
New research reveals how proteins, called “pioneer transcription factors,” help turn on key genes that give cell types their unique properties and functions.
These pioneer factors, it turns out, help unspool tightly wound coils of DNA so that genetic blueprints in genes can be read and proteins that play roles in biological processes can be made.
“We know pretty well what pioneer factors are and what they do, but what we don’t know is how they work exactly,” said first author Julius Judd, a graduate student in the lab of senior author John Lis, professor of molecular biology and genetics in the College of Agriculture and Life Sciences. ....

Julius Judd , Fabiana Duarte , Genes Development , National Institutes Of Health , Life Sciences , College Of Agriculture , Regulate Transcription , John Lis , National Institutes , ஜூலியஸ் தீர்ப்பு , ஃபேபியானா ட்வார்டே , ஜீந்ஸ் வளர்ச்சி , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , வாழ்க்கை அறிவியல் , ஜான் லிஸ் , தேசிய நிறுவனங்கள் ,