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Baricitinib protects β-cell function in new-onset type 1 diabetes

1. In this randomized controlled trial, the Janus kinase (JAK) inhibitor baricitinib was associated with preserved β-cell function compared to placebo in patients with new-onset type 1 diabetes mellitus (T1DM). 2. Patients receiving baricitinib also demonstrated tighter glycemic control compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: The mainstay of T1DM treatment is ....

Minute Medicine Inc , Rating Level , Confidence Interval , Beta Cell , Chronic Disease , Janus Kinase Jak Inhibitor , Type 1 Diabetes , β Cell ,

Teplizumab effective in maintaining β-cell function in type 1 diabetes

1. In this randomized-controlled trial, two 12-day courses of teplizumab improved C-peptide levels compared to placebo at week 78 in patients with stage three type 1 diabetes. 2. No significant differences were observed between the teplizumab and placebo groups with respect to secondary clinical outcomes, including clinically relevant hypoglycemic events. Evidence Rating Level: 1 (Excellent) ....

Drug Administration , Minute Medicine Inc , Rating Level , Provention Bio , Trial Evaluatingc Peptide , Confidence Interval , Chronic Disease , Type 1 Diabetes , β Cell ,