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UVA Aims to Battle Disease by Understanding Exercise's Whole-Body Effects

ARTICLE DATEARTICLE AUTHOR AUTHOR EMAIL
December 09, 2020
A top exercise researcher and colleagues at the University of Virginia School of Medicine have launched an ambitious effort to understand the whole-body benefits of exercise, so that doctors can use that information to prevent and treat disease.
Zhen Yan and his collaborators aim to identify the sources, functions and targets of the molecules that provide exercise’s well-documented health benefits. By understanding this, doctors will better understand how exercise helps fend off disease, and they may be able to design drugs to mimic those benefits for people who cannot exercise, such as those with limited mobility. ....

United States , John Lukens , Zhen Yan , Wenhao Xu , Los Angeles , Dan Addison , Thurl Harris , Matthew Wolf , Chongzhi Zang , Alban Gaultier , Skeletal Muscle Research , University Of California , Robertm Berne Cardiovascular Research Center , University Communications , University Of Iowa , University Of Florida , Department Of Medicine Division Cardiovascular , Department Of Biochemistry , University Of Virginia School Medicine , Department Of Neuroscience , University Of Missouri , Department Of Microbiology , Understanding How Exercise Improves Health , University Of Kansas Medical Center , Public Health Genomics , National Institutes Of Health ,

UB study finds memory deficits resulting from epigenetic changes in Alzheimer's disease can be reversed - UB Now: News and views for UB faculty and staff

Zhen Yan, SUNY Distinguished Professor
Department of Physiology and Biophysics
Memory loss associated with Alzheimer’s disease (AD) may be able to be restored by inhibiting certain enzymes involved in abnormal gene transcription, according to a preclinical study by UB researchers. The findings could pave the way toward new treatments for Alzheimer’s disease.
The paper was published Dec. 9 in Science Advances.
“By treating AD mouse models with a compound to inhibit these enzymes, we were able to normalize gene expression, restore neuronal function and ameliorate cognitive impairment,” says senior author Zhen Yan, SUNY Distinguished Professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB. ....

Wei Wang , Zhen Yan , Qing Cao , Zi Jun Wang , Fengwei Yang , Jamal Williams , Research News , Biomedical Sciences , Department Of Physiology , Jacobs School Of Medicine , Jacobs School , National Institute , National Institutes , வெய் வாங் , ஜென் யான் , குயிங் சாவ் , ஜி ஜூன் வாங் , ஜமால் வில்லியம்ஸ் , ஆராய்ச்சி செய்தி , உயிர் மருத்துவ அறிவியல் , துறை ஆஃப் உடலியல் , ஜாகோப்ஸ் பள்ளி ஆஃப் மருந்து , ஜாகோப்ஸ் பள்ளி , தேசிய நிறுவனம் , தேசிய நிறுவனங்கள் ,