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Innovent Announces the First Patient Dosed in the Phase 1 Study of IBI321 (Anti-PD-1/TIGIT Bispecific Antibody) in Patients with Advanced Malignant Tumors

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SAN FRANCISCO and SUZHOU, China, July 25, 2021 /PRNewswire/ Innovent Biologics, Inc. (Innovent) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high-quality medicines for the treatment of cancer, metabolic, autoimmune and other major diseases, today announced that the first patient has been dosed in a Phase 1 study of IBI321, an anti-PD-1/TIGIT bispecific antibody.
The objective of this open-label, multi-center Phase 1a dose escalation and expansion study is to evaluate the safety, tolerability, potential optimal dosage and preliminary efficacy of IBI321 in patients with advanced malignant tumors whose cancer progressed on standard-of-care treatment. The trial is being conducted in China. ....

United States , Hong Kong , Innovent Biologics , Baohui Han , Adimab Incyte , Xiangdong Cheng , Eli Lilly , Clinical Development Of Innovent , Treatment Technology Research Center , Md Anderson Cancer Center , Respiration Department , Incyte Corporation , Innovent Biologics Inc , Shanghai Chest Hospital , Cancer Hospital , Chinese Academy , Zhejiang Cancer Hospital , Senior Vice President , Clinical Development , Main Board , Stock Exchange , Hong Kong Limited , Biologics License Application , Cancer Center , Mainland China , ஒன்றுபட்டது மாநிலங்களில் ,

Combo Immunotherapy in NSCLC: Not These Two Drugs

Combo Immunotherapy in NSCLC: Not These Two Drugs
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United States , University Of Pennsylvania , Michael Boyer , Fan Yun , Bristol Myers Squibb , Charu Aggarwal , Genentech Roche , Merck Kg , Devika Das , Joshua Bauml , Chris Obrien Lifehouse , Drug Administration , Merck Sharp Dohme Corp , University Of Alabama At Birmingham , Hospital Of The University Pennsylvania , Chriso Brien Lifehouse , Lung Cancer , Penn Medicine , Zhejiang Cancer Hospital , Merck Sharp , Merck Kga , Pfizer Yun , Lung Cancer Singapore , ஒன்றுபட்டது மாநிலங்களில் , கேம்பர் டவுன் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா ,

Dual Checkpoint Blockade No Help in PD-L1-High NSCLC

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Adding a CTLA-4 checkpoint inhibitor to pembrolizumab (Keytruda) failed to improve survival in previously untreated patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression levels, a phase III trial found.
In KEYNOTE 598, the PD-1 checkpoint inhibitor pembrolizumab plus ipilimumab (Yervoy) yielded a median overall survival (OS) of 21.4 months in patients with a tumor proportion score (TPS) of 50% or greater, as compared to 21.9 months with pembrolizumab plus placebo (HR 1.08, 95% CI 0.85-1.37,
P=0.74), reported Michael Boyer, MBBS, PhD, of the University of Sydney.
Median progression-free survival was also no different, at 8.2 months with ipilimumab versus 8.4 months with placebo (HR 1.06, 95% CI 0.86-1.30, ....

New South Wales , Michael Boyer , Fan Yun , University Of Sydney , World Conference , Lung Cancer , Zhejiang Cancer Hospital , Malignant Adenomatous Neoplasm , Mass Of Body Structure , Neoplastic Disease , Psychoactive Substance Dependence , Alcohol Induced Organic Mental Disorder , புதியது தெற்கு வேல்ஸ் , மைக்கேல் பையன் , விசிறி யுன் , பல்கலைக்கழகம் ஆஃப் சிட்னி , உலகம் மாநாடு , நுரையீரல் புற்றுநோய் , ஜெஜியாங் புற்றுநோய் மருத்துவமனை , நிறை ஆஃப் உடல் அமைப்பு ,