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Why cancer cells waste so much energy January 17, 2021MIT In the 1920s, German chemist Otto Warburg discovered that cancer cells don’t metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient. MIT biologists have now found a possible answer to this longstanding question. In a study appearing in Molecular Cell, they showed that this metabolic pathway, known as fermentation, helps cells to regenerate large quantities of a molecule called NAD+, which they need to synthesize DNA and other important molecules. Their findings also account for why other types of rapidly proliferating cells, such as immune cells, switch over to fermentation. ....
MIT Study Reveals Why Cancer Cells Switch to Lethargic Process of Sugar Breakdown FOLLOW US ON: A new study by the scientists of the Massachusetts Institute of Technology (MIT) has found how cancer cells use an unusual process of multiplying. The study, that answers a longstanding mystery on the proliferating unhealthy cells in the human body, will be published in Molecular Cell journal. The study was conducted by MIT biologists Matthew Vander Heiden, senior author of the new study, and the lead authors, former MIT graduate student and postdoc Alba Luengo (PhD ’18) and graduate student, Zhaoqi Li. Their research showed that metabolic procedure, known as fermentation, helps cancer cells to regenerate large quantities of a molecule called NAD+, which they need to synthesize DNA and other important molecules. Speaking to MIT News, Heiden said that according to their study under certain circumstances, cells need to do more of the electron transfer reactions, which ....
Credits: Courtesy of the researchers Terms of Use: Images for download on the MIT News office website are made available to non-commercial entities, press and the general public under a Creative Commons Attribution Non-Commercial No Derivatives license. You may not alter the images provided, other than to crop them to size. A credit line must be used when reproducing images; if one is not provided below, credit the images to MIT. Caption: MIT biologists have found a possible explanation for the Warburg effect, first seen in cancer cells in the 1920s and named after Otto Warburg, pictured. Credits: Image: Digital collage by Jose-Luis Olivares; cancer image courtesy of Dr. Cecil Fox, NCI; Warburg photo courtesy of NIH ....