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Neurotransmitters Collaborate for Odor Detection, Discrimination

Neurotransmitters Collaborate for Odor Detection, Discrimination
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Mikhail Kochukov , Elizabeth Moss , Evelyne Tantry , Benjamin Belfort , Joshua Ortiz Guzman , Ariel Lyons Warren , Zachary Freyberg , Benjamin Arenkiel , University Of Pittsburgh , Mcnair Medical Institute , National Institutes Of Health , Baylor College Of Medicine , Department Of Defense , Dan Duncan Neurological Research Institute , Janice Mcnair Foundation , Baylor College , Mcnair Scholar , Texas Children , National Institutes ,

Single protein could be a new target for delaying onset of aging symptoms in the brain

Single protein could be a new target for delaying onset of aging symptoms in the brain
It is not every day that scientists come across a phenomenon so fundamental that it is observed across fruit flies, rodents and humans.
In a paper published today in
Aging Cell, neuroscientists from the University of Pittsburgh Schools of the Health Sciences discovered that a single protein-;a glutamate transporter on the membrane of vesicles that carry dopamine in neurons-; is key to regulating sex differences in the brain s vulnerability to age-related neuron loss.
The protein-;named VGLUT-;was more abundant in dopamine neurons of female fruit flies, rodents and human beings than in males, correlating with females greater resilience to age-related neuron loss and mobility deficiencies, the researchers found. ....

Zachary Freyberg , Emily Henderson , Pitt Center , University Of Pittsburgh , Aging Cell , Pittsburgh Schools , Health Sciences , Study Senior Author , Assistant Professor , Cell Biology , Silas Buck , எமிலி ஹென்டர்சன் , குழி மையம் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் , பிட்ஸ்பர்க் பள்ளிகள் , ஆரோக்கியம் அறிவியல் , படிப்பு மூத்தவர் நூலாசிரியர் , உதவியாளர் ப்ரொஃபெஸர் , செல் உயிரியல் ,

Protein Linked to Sex Differences in Age-Related Neuron Loss

Date Time
Protein Linked to Sex Differences in Age-Related Neuron Loss
It is not every day that scientists come across a phenomenon so fundamental that it is observed across fruit flies, rodents and humans.
In a paper published today in Aging Cell, neuroscientists from the University of Pittsburgh Schools of the Health Sciences discovered that a single protein a glutamate transporter on the membrane of vesicles that carry dopamine in neurons is key to regulating sex differences in the brain’s vulnerability to age-related neuron loss.
The protein named VGLUT was more abundant in dopamine neurons of female fruit flies, rodents and human beings than in males, correlating with females’ greater resilience to age-related neuron loss and mobility deficiencies, the researchers found. Excitingly, genetically reducing VGLUT levels in female flies diminished their protection from neurodegeneration associated with aging, suggesting that VGLUT could be a new target for pro ....

United States , San Diego , David Lewis , Brian Mccabe , Bryan Logan , Claire Cheetham , Despoina Aslanoglou , Michael Villeneuve , Elizabeth Neureiter , Thomas Hnasko , J Timothy Greenamyre , Gemma Oleary , Sophie Rubin , Jill Glausier , Michael Palladino , Keri Fogle , Thomas Steinkellner , Zachary Freyberg , University Of California , Pitt Center , Swiss Federal Institute Of Technology , University Of Pittsburgh Center , University Of Pittsburgh , Boston University , Aging Cell , Pittsburgh Schools ,

New research suggests how psych meds cause weight gain

New research suggests how psych meds cause weight gain
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Scientists may have uncovered the reason critical medications for schizophrenia and bipolar disorder cause weight gain and diabetes findings they hope will lead to better drugs.
The medications, known as antipsychotics, help control the hallucinations, delusions and confused thoughts that plague people with schizophrenia. They can also help stabilize extreme mood swings in those with bipolar disorder.
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The drugs, which include clozapine, olanzapine, ziprasidone and many others, serve an important purpose, said Dr. Zachary Freyberg, the senior researcher on the new study.
In many cases, he added, they can be life-saving. ....

Ken Duckworth , Zachary Freyberg , University Of Pittsburgh School Medicine , National Alliance On Mental Illness , Pittsburgh School , National Alliance , Translational Psychiatry More , Mental Illness , Translational Psychiatry , கேன் டக்வொர்த் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் பள்ளி மருந்து , தேசிய கூட்டணி ஆன் மன உடல் நலமின்மை , பிட்ஸ்பர்க் பள்ளி , தேசிய கூட்டணி , மொழிபெயர்ப்பு மனநல மருத்துவம் மேலும் , மன உடல் நலமின்மை , மொழிபெயர்ப்பு மனநல மருத்துவம் ,

Study explains why antipsychotic medications lead to weight gain, promote metabolic syndrome

Study explains why antipsychotic medications lead to weight gain, promote metabolic syndrome
Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and develop prediabetes and hyperinsulemia? The question remained a mystery for decades, but in a paper published today in
Translational Psychiatry, researchers from the University of Pittsburgh School of Medicine finally cracked the enigma.
Antipsychotic drugs, scientists showed, not only block dopamine signaling in the brain but also in the pancreas, leading to uncontrolled production of blood glucose-regulating hormones and, eventually, obesity and diabetes.
There are dopamine theories of schizophrenia, drug addiction, depression and neurodegenerative disorders, and we are presenting a dopamine theory of metabolism. We re seeing now that it is not only interesting to study dopamine in the brain, but it is equally interesting and important to study it in ....

Despoina Aslanoglou , Zachary Freyberg , Emily Henderson , University Of Pittsburgh School Medicine , University Of Pittsburgh , Department Of Psychiatry , Translational Psychiatry , Pittsburgh School , Study Lead Author , Postdoctoral Fellow , Bipolar Disorder , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் பள்ளி மருந்து , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் , துறை ஆஃப் மனநல மருத்துவம் , மொழிபெயர்ப்பு மனநல மருத்துவம் , பிட்ஸ்பர்க் பள்ளி , படிப்பு வழி நடத்து நூலாசிரியர் , போஸ்ட்‌டாக்டொரல் சக , இருமுனை கோளாறு , நீரிழிவு நோய் , வளர்சிதை மாற்றம் , உடல் பருமன் , மனநல மருத்துவம் ,