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Protein Linked to Sex Differences in Age-Related Neuron Loss

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Protein Linked to Sex Differences in Age-Related Neuron Loss
It is not every day that scientists come across a phenomenon so fundamental that it is observed across fruit flies, rodents and humans.
In a paper published today in Aging Cell, neuroscientists from the University of Pittsburgh Schools of the Health Sciences discovered that a single protein a glutamate transporter on the membrane of vesicles that carry dopamine in neurons is key to regulating sex differences in the brain’s vulnerability to age-related neuron loss.
The protein named VGLUT was more abundant in dopamine neurons of female fruit flies, rodents and human beings than in males, correlating with females’ greater resilience to age-related neuron loss and mobility deficiencies, the researchers found. Excitingly, genetically reducing VGLUT levels in female flies diminished their protection from neurodegeneration associated with aging, suggesting that VGLUT could be a new target for pro ....

United States , San Diego , David Lewis , Brian Mccabe , Bryan Logan , Claire Cheetham , Despoina Aslanoglou , Michael Villeneuve , Elizabeth Neureiter , Thomas Hnasko , J Timothy Greenamyre , Gemma Oleary , Sophie Rubin , Jill Glausier , Michael Palladino , Keri Fogle , Thomas Steinkellner , Zachary Freyberg , University Of California , Pitt Center , Swiss Federal Institute Of Technology , University Of Pittsburgh Center , University Of Pittsburgh , Boston University , Aging Cell , Pittsburgh Schools ,

Study explains why antipsychotic medications lead to weight gain, promote metabolic syndrome

Study explains why antipsychotic medications lead to weight gain, promote metabolic syndrome
Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and develop prediabetes and hyperinsulemia? The question remained a mystery for decades, but in a paper published today in
Translational Psychiatry, researchers from the University of Pittsburgh School of Medicine finally cracked the enigma.
Antipsychotic drugs, scientists showed, not only block dopamine signaling in the brain but also in the pancreas, leading to uncontrolled production of blood glucose-regulating hormones and, eventually, obesity and diabetes.
There are dopamine theories of schizophrenia, drug addiction, depression and neurodegenerative disorders, and we are presenting a dopamine theory of metabolism. We re seeing now that it is not only interesting to study dopamine in the brain, but it is equally interesting and important to study it in ....

Despoina Aslanoglou , Zachary Freyberg , Emily Henderson , University Of Pittsburgh School Medicine , University Of Pittsburgh , Department Of Psychiatry , Translational Psychiatry , Pittsburgh School , Study Lead Author , Postdoctoral Fellow , Bipolar Disorder , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் பள்ளி மருந்து , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் , துறை ஆஃப் மனநல மருத்துவம் , மொழிபெயர்ப்பு மனநல மருத்துவம் , பிட்ஸ்பர்க் பள்ளி , படிப்பு வழி நடத்து நூலாசிரியர் , போஸ்ட்‌டாக்டொரல் சக , இருமுனை கோளாறு , நீரிழிவு நோய் , வளர்சிதை மாற்றம் , உடல் பருமன் , மனநல மருத்துவம் ,