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Antioxidant Found in Green Tea May Increase Levels of p53


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An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the “guardian of the genome” for its ability to repair DNA damage or destroy cancerous cells. Published today in Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery.
“Both p53 and EGCG molecules are extremely interesting. Mutations in p53 are found in over 50% of human cancer, while EGCG is the major anti-oxidant in green tea, a popular beverage worldwide,” said Chunyu Wang, corresponding author and a professor of biological sciences at Rensselaer Polytechnic Institute. “Now we find that there is a previously unknown, direct interaction between the two, which points to a new path for developing anti-cancer drugs. Our work helps to explain how EGCG is able to boost p53’s anti-cancer activity, opening the do ....

Jing Zhao , United States , University Of Massachusetts , Lauren Gandy , Yingkai Zhang , Curt Breneman , Jianhan Chen , Chunyu Wang , Weihua Jin , Sozanne Solmaz , Xinyue Liu , Stewart Loh , Michael Cosgrove , Yuanyuan Xiao , Alan Blaney , Lufeng Yan , Nature Communications , University Massachusetts , Merck Research Laboratories , Binghamton University , National Institutes Of Health , Rensselaer Polytechnic Institute , Rensselaer School Of Science , Rensselaer Center , China Agricultural University , York University ,

Major antioxidant in green tea may increase levels of natural anti-cancer protein


Major antioxidant in green tea may increase levels of natural anti-cancer protein
An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the guardian of the genome for its ability to repair DNA damage or destroy cancerous cells. Published today in
Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery.
Both p53 and EGCG molecules are extremely interesting. Mutations in p53 are found in over 50% of human cancer, while EGCG is the major anti-oxidant in green tea, a popular beverage worldwide. Now we find that there is a previously unknown, direct interaction between the two, which points to a new path for developing anti-cancer drugs. Our work helps to explain how EGCG is able to boost p53 s anti-cancer activity, opening the door to developing drugs with EGCG-like compounds. ....

Jing Zhao , Lauren Gandy , Chunyu Wang , Weihua Jin , Emily Henderson , Xinyue Liu , Yuanyuan Xiao , Lufeng Yan , Alan Blaney , Nature Communications , Merck Research Laboratories , National Institutes Of Health , Rensselaer Polytechnic Institute , Rensselaer Center , China Agricultural University , Professor Of Biological Sciences , University Of Massachusetts , University Of New York At Binghamton , York University , Corresponding Author , Biological Sciences , Rensselaer Polytechnic , Interdisciplinary Studies , Intrinsically Disorderedn Terminal Domain , National Institutes , Upstate Medical ,