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Meta-analysis shows SGLT2 inhibitors not beneficial in treating COVID-19 healio.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from healio.com Daily Mail and Mail on Sunday newspapers.
Semaglutide drives 'substantial' improvements in heart failure symptoms: STEP-HFpEF healio.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from healio.com Daily Mail and Mail on Sunday newspapers.
: Semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with heart failure with preserved ejection fraction (HFpEF) and obesity, according to late breaking research presented in a Hot Line session today at ESC Congress 2023. Approximately half of patients with heart failure in the community have HFpEF.2 Most patients with HFpEF are overweight or obese, and growing evidence suggests that obesity and excess adiposity are not simply comorbidities, but may play a pivotal role in the development and progression of HFpEF.3 Patients with obesity-related HFpEF have an especially high burden of debilitating symptoms (shortness of breath, exertional intolerance, swelling/oedema) and physical limitations, which collectively result in a poor quality of life.4,5 Few treatment options are available, and there are no approved therapies specifically targeting the obesity phenotype of HFpEF. ....
Compared with reduced-dose prophylaxis, full-dose anticoagulation cut thrombotic events but also boosted bleeding in patients with COVID-19 who needed ICU admission. ....