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Tear glands in a dish can cry

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Credit: Marie Bannier-Hélaouët, Hubrecht Institute
Stem-cell-derived organoids that swell up with tears could shed light on the biology of crying and dry-eye disease, suggests a study publishing March 16 in the journal
Cell Stem Cell. Although regenerative therapies using human tear-gland organoids will not be possible anytime soon, these researchers have demonstrated that the organoids can engraft, integrate, and produce mature tear products upon transplantation into mouse tear glands.
We hope that scientists will use our model to identify new treatment options for patients with tear-gland disorders by either testing new drugs on a patient s organoids or expanding healthy cells and, one day, using them for transplantation, says senior study author Hans Clevers (@HansClevers) of the Hubrecht Institute. ....

Marie Bannier , Hans Clevers Hansclevers , Netherlands Organisation For Scientific Research , Yorick Post Of The Hubrecht Institute , Leducq Foundation , Hubrecht Institute , Cell Stem , Hans Clevers , Yorick Post , Marie Bannier H , Netherlands Organisation , Scientific Research , Stem Cell , Cell Press , Cell Biology , Developmental Reproductive Biology , நெதர்லாந்து ஆர்கநைஸேஶந் க்கு அறிவியல் ஆராய்ச்சி , செல் தண்டு , நெதர்லாந்து ஆர்கநைஸேஶந் , அறிவியல் ஆராய்ச்சி , தண்டு செல் , செல் ப்ரெஸ் , செல் உயிரியல் , வளர்ச்சி இனப்பெருக்கம் உயிரியல் ,

Lab scientists grow mini human tear glands that cry

Using new organoid technology, scientists have grown miniature tear glands that actually cry. They hope the organic models can be used to develop treatments for tear gland disorders, and eventually for transplants. ....

Rachel Kalmann , Marie Bannier , University Medical Center Utrecht , Hubrecht Institute , Cell Stem , Marie Bannier H , Yorick Post , பல்கலைக்கழகம் மருத்துவ மையம் அட்ரெக்ட் , செல் தண்டு ,

Tear Glands Grown in Lab Can Cry

A new study yields fascinating results that promise a possible solution to dry-eye disease and a step toward regenerative medicine.
This image shows a confocal image of a mouse lacrimal-gland organoid with the tear product Lcn2 labelled in red, showing that the organoids make tears. (Yorick Post, Hubrecht Institute)
(CN) Trailblazing scientists have revealed a promising future in the search for treatment of dry-eye disease by using an innovative new technique to create miniature organs called organoids for testing.
This method, in which tissue obtained from stem cells is able to self-organize under optimal conditions in a lab, creates a three dimensional collection of cells known as organoids, capable of performing the same functions as an organ. ....

Hans Clevers , Marie Bannier , Hubrecht Institute , Yorick Post , Cell Stem , Netherlands Based Hubrecht Institute , Marie Bannier H , செல் தண்டு ,