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[Full text] KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic R


Reverse Transcription Quantitative PCR (RT-qPCR)
Following total RNA extraction using TRIzol reagent (Invitrogen), cDNA was synthesized using Mir-X miRNA First-Strand Synthesis Kit (Takara Holdings Inc., Kyoto, Japan) with extracted total RNA (2 μg). The miRNA expression was measured by qPCR with SYBR Advantage qPCR Premix (Takara) on CFX133a Real-Time PCR Detection System (Bio-Rad Laboratories, Hercules, CA, USA). Relative expression was determined with a U6 control through the 2
−ΔΔCt method. The primers used are depicted in Table 1.
Table 1 Primer Sequences
Cell Culture, Transfection and Infection
Human lung cancer cell lines, including H522, H460, SK-MES-1, and A549, and a human bronchial epithelial cell line BEAS-2B, were from the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (Shanghai, China). Cell lines H522, H460, and A549 were cultivated in RPMI-1640 medium (Gibco; Thermo Fisher Scientific), while SK-MES-1 cells were in m ....

United States , Switzerland General , United Kingdom , Eteläuomen Läi , Santa Clara , Lonza Clonetics , Laboratory Animal Co Ltd , Committee Of People Hospital Zhengzhou University , Chinese Academy Of Sciences Shanghai , Biotech Co Ltd , People Hospital Of Zhengzhou University , Invitrogen Inc , Co Ltd , Olympus Optical Co Ltd , Institute Of Biochemistry , Strand Synthesis Kit Takara Holdings Inc , Thermo Fisher Scientific Inc , Us National Institutes Of Health , Yeasen Biotechnology Co Ltd , Promega Corporation , Cancer Genome Atlas , Research Ethics Committee , Zhengzhou University , Agilent Technologies , Agilent Human , Garber Lung ,