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Intestinal cells can change specializations during their lives, finds study

Intestinal cells can change specializations during their lives. The BMP signaling pathway – an important communication mechanism between cells – appears to be the driver of these changes. ....

Guang Chen , Jens Puschhof , Hans Clevers , Hans Clevers Hubrecht Instituut , Joep Beumer , Fjodor Yousef Yengej , Emily Henderson , Guang Chen Tshinghua University , Hubrecht Institute , Guang Chen Tsinghua University , Hubrecht Instituut , Ye Guang Chen , Tshinghua University , Cell Reports , Tsinghua University , Fjodor Yousef , Ouse Model , Ignaling Pathway ,

Changing Intestinal Cell Function May Inform on Metabolic Disease Targets

Results suggest potential of intestine-specific BMP inhibition for diseases involving excess lipid uptake from food. ....

Guang Chen , Jens Puschhof , Hans Clevers , Joep Beumer , Fjodor Yousef Yengej , Hubrecht Institute , Tsinghua University , Ye Guang Chen , Cell Reports ,