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Anton 2 Simulations Reveal 'Invisible' Protein Movements

Anton 2 Simulations Reveal 'Invisible' Protein Movements
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United States , San Diego , American River College , Yanxiao Han , Igor Vorobyov , University Of California , Va Northern California Health Care System , Texas Advanced Computing Center , San Diego Supercomputer Center , National Institutes Of Health , De Shaw Research , Shaw Research , California Health Care System , National Institutes , National Academy , Sciences United States ,

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins

Novel strategy redirects generic antibodies to SARS-CoV-2 spike proteins
The SARS-CoV-2, the new coronavirus behind the current pandemic, infects humans by binding its surface-exposed spike proteins to ACE2 receptors exposed on the cell membranes.
Upon a vaccination or a real infection, it takes several weeks before the immunity develops antibodies that can selectively bind to these spike proteins. Such antibody-labeled viruses are neutralized by the natural killer and T cells operated by the human immunity.
An alternative approach to train the immunity response is offered by researchers at the University of Illinois Chicago and California State University at Sacramento who have developed a novel strategy that redirects antibodies for other diseases existing in humans to the spike proteins of SARS-CoV-2. ....

United States , Yanxiao Han , Emily Henderson , California State University At Sacramento , University Of Illinois Chicago , Illinois Chicago , California State University , Physical Chemistry Letters , Study Senior Author , Pharmaceutical Sciences , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , கலிஃபோர்னியா நிலை பல்கலைக்கழகம் இல் சாக்ரமென்டோ , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் சிகாகோ , இல்லினாய்ஸ் சிகாகோ , கலிஃபோர்னியா நிலை பல்கலைக்கழகம் , உடல் வேதியியல் எழுத்துக்கள் , படிப்பு மூத்தவர் நூலாசிரியர் , மருந்து அறிவியல் ,

Retrained generic antibodies can recognize SARS-CoV-2

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IMAGE: Double-faced peptide-based boosters are computationally designed to allow recognition of SARS-CoV-2 (grey, schematic) by Hepatitis B antibodies. One booster face made of ACE2-mimic peptides (red) can bind to the receptor.
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Credit: UIC
The SARS-CoV-2, the new coronavirus behind the current pandemic, infects humans by binding its surface-exposed spike proteins to ACE2 receptors exposed on the cell membranes.
Upon a vaccination or a real infection, it takes several weeks before the immunity develops antibodies that can selectively bind to these spike proteins. Such antibody-labeled viruses are neutralized by the natural killer and T cells operated by the human immunity. ....

United States , Yanxiao Han , Katherine Mcreynolds , California State University At Sacramento , University Of Illinois Chicago , Illinois Chicago , California State University , Physical Chemistry Letters , ஒன்றுபட்டது மாநிலங்களில் , க்யாதரிந் ம்க்ரெய்நொல்ட்ஸ் , கலிஃபோர்னியா நிலை பல்கலைக்கழகம் இல் சாக்ரமென்டோ , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் சிகாகோ , இல்லினாய்ஸ் சிகாகோ , கலிஃபோர்னியா நிலை பல்கலைக்கழகம் , உடல் வேதியியல் எழுத்துக்கள் ,