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Freeze! Executioner protein caught in the act


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IMAGE: A cell in yellow is shown dying by necroptosis, a process requiring the protein MLKL
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Credit: WEHI Australia
A new molecular freeze frame technique has allowed WEHI researchers to see key steps in how the protein MLKL kills cells.
Small proteins called monobodies were used to freeze MLKL at different stages as it moved from a dormant to an activated state, a key process that enables an inflammatory form of cell death called necroptosis. The team were able to map how the three-dimensional structure of MLKL changed, revealing potential target sites that might be targets for drugs - a potential new approach to blocking necroptosis as a treatment for inflammatory diseases. ....

Akiko Koide , Shohei Koide , Yanxiang Meng , James Murphy , Department Of Education , Engineering Postgraduate Research Award , Australian Institute Of Nuclear Science , Nature Communications , Melbourne Research Scholarship , Australian Government National Health , Australian Cancer Research Foundation , York University , Us National Institutes Of Health , Research Council , Associate Professor James Murphy , Assistant Professor Akiko Koide , Professor Shohei Koide , New York University , Professor Koide , Professor Murphy , Medical Research Council , Wendy Dowsett Scholarship , Australian Institute , Nuclear Science , Cell Biology , Medicine Health ,