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Prostate Cancer Drug Shows Promise Against COVID

Prostate Cancer Drug Shows Promise Against COVID
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Michigan Center , United States , Jun Qin , Yuanyuan Qiao , Jessew Wotring , Jonathan Sexton , Charlesj Zhang , Rui Wang , Kelly Malcom , Sanjana Eyunni , Abhijit Parolia , Stephaniej Ellison , Liandong Ma , Honghua Yan , Arul Chinnaiyan , Carlad Pretto , Fengyun Su , Yang Zheng , Caleb Cheng , Yini Wang , Xia Jiang , Yuping Zhang , Qianxiang Zhou , Xuhong Cao , University Of Michigan Medical School , Yum Center ,

Promising COVID Treatment Found in Prostate Cancer Drug

Promising COVID Treatment Found in Prostate Cancer Drug
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Michigan Center , United States , Abhijit Parolia , Carlad Pretto , Charlesj Zhang , Yuanyuan Qiao , Xuhong Cao , Yini Wang , Stephaniej Ellison , Yuping Zhang , Caleb Cheng , Jonathan Sexton , Sanjana Eyunni , Arul Chinnaiyan , Yang Zheng , Rui Wang , Liandong Ma , Honghua Yan , Qianxiang Zhou , Jessew Wotring , Jun Qin , Xia Jiang , Fengyun Su , College Of Pharmacy , Yum Center , University Of Michigan Medical School ,

Scientists find link between genetic mutations and cancer treatment resistance

Scientists find link between genetic mutations and cancer treatment resistance
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Michigan Center , United States , Wallace Kb Chan , Yi Mi Wu , Alexanderc Hopkins , Alexander Tsodikov , Xuhong Cao , Moshe Talpaz , Daniel Auclair , Jeanmarie Mishler , Danr Robinson , Arvind Rao , A Alfred Taubman , Sarah Hall , Jennifer Yesil , Craige Cole , Dan Robinson , Rahul Mannan , Arul Chinnaiyan , P Leif Bergsagel , Hearn Jay Cho , Jamesc Estill , Elisha Wang , Jin Zhou , Nature Communications , National Cancer Institute ,

Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead


Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead
ANN ARBOR, Michigan By taking a lesson from prostate cancer, researchers now have a promising lead on a treatment for COVID-19.
Two proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, M.D., Ph.D. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers. They also knew that TMPRSS2 was regulated by the androgen receptor.
So when cancer research shut down in the spring, Chinnaiyan s lab turned its attention to the coronavirus. With a grant from the National Cancer Institute, the team used its existing knowledge and resources to determine how TMPRSS2 was regulated in the lungs. ....

Michigan Center , United States , Gregory Raskind , Jonathanz Sexton , Stephaniea Simko , Jessew Wotring , Jean Ching Yi Tien , Sylvia Zelenka Wang , Steven Kregel , Sathiyap Narayanan , Pushpinder Bawa , Ingridj Apel , Xuhong Cao , Abhijit Parolia , Fengyun Su , Lanbo Xiao , Rohit Mehra , Danr Robinson , Xiaoming Wang , Yuanyuan Qiao , Stephaniej Ellison , Rahul Mannan , Arul Chinnaiyan , Yuping Zhang , Lisa Mcmurry , Sethuramasundaram Pitchiaya ,