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Distinct Parkinson's Disease Symptoms Tied to Different Brain Pathways


Distinct Parkinson’s Disease Symptoms Tied to Different Brain Pathways
Identification of neural circuits clarifies motor vs. cognitive symptoms, aiding efforts to improve treatments
Lim Lab, UC San Diego
A three-dimensional rendering of a mouse hemisphere shows brain-wide projection patterns of GPe neurons labeled by mRuby2 (soma, axonal fibers) and eGFP (pre-synaptic sites).
Newswise Parkinson’s disease (PD) is well known as a debilitating disease that gradually worsens over time. Although the disease’s progression has been largely tied to the loss of motor functions, non-motor symptoms, including the loss of cognitive abilities, often emerge early in the disease.
Much less understood is the role that specific neural circuits play in these distinct motor and non-motor functions. ....

Horia Pribiag , Christopher Dabin Yoon , Eric Hou Jen Wang , Kwanghun Chung , Amanda Ngoc Tran , Jun Hyeok Choi , Xiao Yun Wang , Varoth Lilascharoen , Stefan Carl Pate , Anandamahidol Foundation Fellowship , University Of California San Diego , National Institutes Of Health , California San Diego , Nature Neuroscience , Neurobiology Section , Biological Sciences , Young Gyun Park , National Institutes , Brain Neurons Basal Ganglia Parkinsons Disease Neural Circuit Mapping Behavior Pathways , All Journal News , Parkinsons Disease , National Institutes Of Health Nih , எரிக் ஹூ ஜென் வாங் , அமண்டா ந்காக் டிரான் , கிஷியஓ யுன் வாங் , ஸ்டீபன் கார்ல் பட்டே ,