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Epigenomic Map Identifies Candidate Mechanisms for 30,000 Gene Loci Linked to 540 Traits


Epigenomic Map Identifies Candidate Mechanisms for 30,000 Gene Loci Linked to 540 Traits
February 4, 2021
A team of researchers at Massachusetts Institute of Technology (MIT) has published what it claims is the most comprehensive map yet of human noncoding DNA. The EpiMap (Epigenome Integration across Multiple Annotation Projects) resource offers an in-depth annotation of epigenomic marks modifications indicating which genes are turned on or off in different types of cells across 833 tissues and cell types. This represents a significant increase over prior coverage, the team said.
The researchers also identified groups of regulatory elements that control specific biological programs, and uncovered candidate mechanisms of action for about 30,000 genetic variants linked to 540 specific traits. They have made all of their data publicly available for use by the broader scientific community. ....

United Kingdom , Carles Boix , Manolis Kellis , Wouter Meuleman , Benjamin James , Broad Institute , Artificial Intelligence Laboratory , University Of British Columbia , Massachusetts Institute Of Technology , Altius Institute For Biomedical Sciences , Massachusetts Institute , Epigenome Integration , Multiple Annotation Projects , Yongjin Park , British Columbia , Altius Institute , Biomedical Sciences , Roadmap Epigenomics , ஒன்றுபட்டது கிஂக்டம் , பெஞ்சமின் ஜேம்ஸ் , பரந்த நிறுவனம் , செயற்கை உளவுத்துறை ஆய்வகம் , பல்கலைக்கழகம் ஆஃப் பிரிட்டிஷ் கொலம்பியா , மாசசூசெட்ஸ் நிறுவனம் ஆஃப் தொழில்நுட்பம் , ஆல்டிஸ் நிறுவனம் க்கு உயிர் மருத்துவ அறிவியல் , மாசசூசெட்ஸ் நிறுவனம் ,

Epigenomic map reveals circuitry of 30,000 human disease regions


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CAMBRIDGE, MA Twenty years ago this month, the first draft of the human genome was publicly released. One of the major surprises that came from that project was the revelation that only 1.5 percent of the human genome consists of protein-coding genes.
Over the past two decades, it has become apparent that those noncoding stretches of DNA, originally thought to be junk DNA, play critical roles in development and gene regulation. In a new study published today, a team of researchers from MIT has published the most comprehensive map yet of this noncoding DNA.
This map provides in-depth annotation of epigenomic marks modifications indicating which genes are turned on or off in different types of cells across 833 tissues and cell types, a significant increase over what has been covered before. The researchers also identified groups of regulatory elements that control specific biological programs, and they uncovered candidate mechanisms of action for about 3 ....

United Kingdom , Carles Boix , Manolis Kellis , Wouter Meuleman , Benjamin James , Broad Institute , Artificial Intelligence Laboratory , University Of British Columbia , National Institutes Of Health , Altius Institute For Biomedical Sciences , Yongjin Park , British Columbia , Altius Institute , Biomedical Sciences , Epigenome Integration , Multiple Annotation Projects , Roadmap Epigenomics , National Institutes , ஒன்றுபட்டது கிஂக்டம் , பெஞ்சமின் ஜேம்ஸ் , பரந்த நிறுவனம் , செயற்கை உளவுத்துறை ஆய்வகம் , பல்கலைக்கழகம் ஆஃப் பிரிட்டிஷ் கொலம்பியா , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஆல்டிஸ் நிறுவனம் க்கு உயிர் மருத்துவ அறிவியல் , பிரிட்டிஷ் கொலம்பியா ,