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Results of a new clinical trial published in Nature Medicine show that a novel, personalized neoantigen vaccine therapy demonstrated promising anti-tumor effica ....

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Promising Personalized Approach to Liver Cancer Therapy Made Possible by DNA-based Neoantigen Research Designed at The Wistar Institute

Promising Personalized Approach to Liver Cancer Therapy Made Possible by DNA-based Neoantigen Research Designed at The Wistar Institute
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Results of a new clinical trial published in Nature Medicine show that a novel, personalized neoantigen vaccine therapy demonstrated promising anti-tumor effica ....

United States , Davidb Weiner , Vaccine Immunotherapy Center , Wistar Institute , Wistar Institute Vaccine Immunotherapy Center , Nature Medicineshow , Geneos Therapeutics , Response Evaluation Criteria , Solid Tumors , Wistar Institute Vaccine , Wistar Executive Vice President , Charitable Trust Distinguished Professor , Cancer Research , Eoantigen Vaccine Therapy Liver Cancer Research Hepatocellular Carcinoma Immunologically Cold , Wistar Institute ,

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models
A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen.
A similar vaccine candidate was previously shown to be safe and tolerable with a three-dose intramuscular injection regimen in a recently completed human phase 1 study and is currently in expanded studies of phase 1/2a trial. New results were published today in
JCI Insight.
While several vaccine products are being advanced against MERS and other coronaviruses, low-dose delivery and shortened regimes are crucial to rapidly induce protective immunity, particularly during emerging outbreaks, as the current SARS-CoV-2 pandemic has emphasized. ....

Davidb Weiner , Emmal Reuschel , Emily Henderson , Vaccine Immunotherapy Center , Wistar Institute , Middle East , Wistar Executive Vice President , Charitable Trust Professor , Ami Patel , Caspar Wistar Fellow , எமிலி ஹென்டர்சன் , தடுப்பூசி நோயெதிர்ப்பு சிகிச்சை மையம் , நடுத்தர கிழக்கு , தொண்டு நம்பிக்கை ப்ரொஃபெஸர் , அமி படேல் ,