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Prof. Franklin Pugh, Chitvan Mittal grad, Olivia Lang grad, and William K.M. Lai grad highlights new understandings of how the epigenome impacts transcription within cells. ....
The 3Rs of the genome: Reading, writing and regulating psu.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from psu.edu Daily Mail and Mail on Sunday newspapers.
E-Mail IMAGE: Researchers have precisely mapped the binding locations of over 400 proteins on the yeast genome using ChIP-exo. The method (top) uses an antibody to fish out a specific DNA-bound protein. view more Credit: Pugh Lab, Cornell and Mahony Lab, Penn State A massive effort to map the precise binding locations of over 400 different kinds of proteins on the yeast genome has produced the most thorough and high-resolution map of chromosome architecture and gene regulation to date. The study reveals two distinct gene regulatory architectures, expanding the traditional model of gene regulation. So-called constitutive genes, those that perform basic housekeeping functions and are nearly always active at low levels require only a basic set of regulatory controls; whereas those that that are activated by environmental signals, known as inducible genes, have a more specialized architecture. This finding in yeast could open the door to a better unders ....
A new Penn State and Cornell study describes an effort to produce the most comprehensive and high-resolution map yet of chromosome architecture and gene regulation in yeast. ....