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Blocking Notch Signalling Lessens Age Related Bone Loss

A cellular signal essential to the development and repair of the skeleton increases abnormally during aging to weaken bones. The study found that blocking this pathway in aging skeletal stem cells caused a “massive increase” in bone mass. ....

Philipp Leucht , Notch Signaling Impacts Bone Health , Langone Health , Bone Research , Grossman School Of Medicine , Department Of Orthopedic Surgery , Technology Network , Signaling Impacts Bone Health , Bone Mass , Therapeutic Target , While Notch , Raj Sobti Menon Associate Professor , Orthopedic Surgery , Lindsey Remark ,