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Third-generation anti-CD19 CAR T-cells demons

<ul>
<li>Adding a new CAR co-stimulatory domain (TLR2) to a conventional CD28-costimulated anti-CD19 CAR T-cell reduces cytokine release syndrome- and neurotoxicity-associated cytokines.</li>
<li>25 patients with relapsed or refractory B-cell non-Hodgkin lymphomas received CD28/TLR2 co-stimulated anti-CD19 CAR T-cells in a phase 1 dose escalation and expansion trial.</li>
<li>No severe CRS and no ICANS neurotoxicity of any grade occurred. Complete responses were seen at doses from 5 × 10<sup>4</sup> to 1 × 10<sup>6</sup> cells/kg.</li>
<li>Outpatient therapy and automated manufacture have been established in preparation for a phase 2 trial.</li>
</ul>
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3Rd Gen Anti-CD19 CAR T-Cells Demonstrate Efficacy Without Neurotoxicity In B-Cell Lymphoma Phase 1 Clinical Trial

3Rd Gen Anti-CD19 CAR T-Cells Demonstrate Efficacy Without Neurotoxicity In B-Cell Lymphoma Phase 1 Clinical Trial
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Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

The Malaghan Institute of Medical Research in collaboration with Wellington Zhaotai Therapies Limited today announced results of its phase 1 dose escalation trial of a new third-generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December, 3pm. ....

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Third-generation anti-CD19 CAR T-cells show efficacy without neurotoxicity in B-cell lymphoma phase 1 clinical trial

Third-generation anti-CD19 CAR T-cells show efficacy without neurotoxicity in B-cell lymphoma phase 1 clinical trial
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3rd Gen Anti-CD19 CAR T-Cells Prove Effective, Non-Toxic in Trial

3rd Gen Anti-CD19 CAR T-Cells Prove Effective, Non-Toxic in Trial
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