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HIV therapy has detrimental effect on children's growth and bone strength, landmark study finds


London School of Hygiene & Tropical Medicine
Link identified between HIV drug and skeletal deficits in Zimbabwean children
Children growing up with HIV infection have concerning deficits in skeletal strength which become more apparent towards the end of pubertal growth, finds the new research in The Lancet Child and Adolescent Health.
In the largest study to date to investigate the link between HIV and skeletal health in children, the researchers found a potential association between these skeletal deficits and the first-line antiretroviral-HIV drug, tenofovir disproxil fumarate (TDF), which is widely used across sub-Saharan Africa.
The research was carried out by the London School of Hygiene & Tropical Medicine (LSHTM), the University of Zimbabwe, the University of Bristol and the Biomedical Training and Research Institute in Zimbabwe. The findings raise concerns for the long-term impact of this drug on the skeletal health of adolescents across the region, as they ....

Mashonaland East , Ruramayi Rukuni , Rashida Ferrand , Celia Gregson , London School Of Hygiene Tropical Medicine , Wellcome Trust Ph , Research Institute , Professor Of Clinical Epidemiology At Bristol University , University Of Zimbabwe , Professor Of International Health , University Of Bristol , Lancet Child , London School , Tropical Medicine , Biomedical Training , Saharan Africa , International Health , Wellcome Trust Phd Fellow , Clinical Epidemiology , Bristol University , மஷோனலண்ட் கிழக்கு , ரஷிதா ஃபெரண்ட் , செலியா கிரெக்சன் , லண்டன் பள்ளி ஆஃப் சுகாதாரம் வெப்பமண்டல மருந்து , வெல்கம் நம்பிக்கை பீயெச் , ஆராய்ச்சி நிறுவனம் ,