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Samuel Little, most prolific serial killer and former San Diego resident, dies at age of 80 Samuel Little, most prolific serial killer and former San Diego resident, dies at age of 80 and last updated 2020-12-31 22:24:30-05 SAN DIEGO (KGTV) - Samuel Little, the man the FBI calls the most prolific serial killer in US history has died. Little was convicted for several violent crimes he committed in San Diego when he lived in the area in 1984. In my mind he represented an evil person, and the world is better without him, said Wayne Spees, a former San Diego police officer who arrested Little in 1984. ....