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E-Mail IMAGE: Jing-Qiong (Katty) Kang, M.D., Ph.D., associate professor of Neurology and Pharmacology, Vanderbilt University Medical Center. view more Credit: Vanderbilt University Medical Center Researchers at Vanderbilt University Medical Center (VUMC) have identified a common mechanism underlying a spectrum of epilepsy syndromes and neurodevelopmental disorders, including autism, that are caused by variations in a gene encoding a vital transporter protein in the brain. Their findings, reported last month in the journal Brain, suggest that boosting transporter function via genetic or pharmacological means could be beneficial in treating brain disorders linked to these genetic variations. This points (to) a clear direction of treating a wide spectrum of neurodevelopmental disorders, from various epilepsy syndromes (and) autism to neurodevelopmental delay and intellectual disabilities, caused by the pathological variants in this gene, sai ....
Date Time Trans-institutional collaboration receives $2 million BRAIN Initiative grant Vivian Gama, assistant professor of cell and developmental biology, and Leon Bellan, associate professor of mechanical engineering and biomedical engineering, have won a $2.3 million, three-year grant from the National Institutes of Health Brain Research through Advancing Innovative Neurotechnologies Initiative. Vivian Gama Leon Bellan (Vanderbilt University) The researchers will be developing three-dimensional brain organoids and related tissue–miniaturized and simplified versions produced in vitro–that resemble a human brain at 24 to 25 weeks post-conception. These will provide an unparalleled window into brain development and potentially into currently untreatable neurological disorders. The grant will bring together researchers including Ethan Lippmann, assistant professor of chemical and biomedical engineering, Jose A. Gomez, assistant professor of medicine, and Jul ....