Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 million base pairs away from the target., , , , To enable those interactions, the genome loops itself in a 3D structure that brings distant regions close together. Using a new technique, MIT researchers have shown that they can map these interactions with 100 times higher resolution than has previously.
An unprecedented view of gene regulation: Engineers' new technique analyzes the 3D organization of the genome at a resolution 100 times higher than before sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.
Using a new technique, MIT researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.