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Technique Reveals 3D Genome Interactions |

Researchers at MIT have developed a method that allows them to analyze the three dimensional interactions of sections of the genome in unprecedented ....

Viraat Goel , Anders Sejr Hansen , Region Capture Micro C , Nature Genetics ,

New technique generates highest-resolution maps of the 3D genome

Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. ....

United States , University Of Massachusetts Medical School , Stanley Hsieh , Oliver Rando , Viraat Goel , Emily Henderson , Anders Sejr Hansen , Umass Medical School , National Cancer Institute , Koch Institute , Koch Institute Frontier Research Fund , University Of California At Berkeley , Harvard Medical School , Solomon Buchsbaum Research Support Committee Award , National Institutes Of Health , National Science Foundation , Sejr Hansen , Biological Engineering , Miles Huseyin , Massachusetts Medical School , Region Capture Micro C , Boston Children , Koch Institute Support , National Institutes , Medical School ,

An unprecedented view of gene regulation

Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 million base pairs away from the target., , , , To enable those interactions, the genome loops itself in a 3D structure that brings distant regions close together. Using a new technique, MIT researchers have shown that they can map these interactions with 100 times higher resolution than has previously. ....

University Of Massachusetts Medical School , United States , Anders Sejr Hansen , Christine Eyler , Viraat Goel , Stanley Hsieh , Oliver Rando , National Science Foundation , Harvard Medical School , National Institutes Of Health , University Of California At Berkeley , Koch Institute , National Cancer Institute , Duke University School Of Medicine , Koch Institute Frontier Research Fund , Solomon Buchsbaum Research Support Committee Award , Umass Medical School , Biological Engineering , Miles Huseyin , Massachusetts Medical School , Region Capture Micro C , Boston Children , Duke University School , Koch Institute Support , National Institutes , Press Release Image ,

An unprecedented view of gene regulation: Engineers' new technique analyzes the 3D organization of the genome at a resolution 100 times higher than before

An unprecedented view of gene regulation: Engineers' new technique analyzes the 3D organization of the genome at a resolution 100 times higher than before
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United States , University Of Massachusetts Medical School , Stanley Hsieh , Viraat Goel , Oliver Rando , Anders Sejr Hansen , National Institutes Of Health , Solomon Buchsbaum Research Support Committee Award , Harvard Medical School , National Cancer Institute , National Science Foundation , Umass Medical School , Koch Institute , University Of California At Berkeley , Koch Institute Frontier Research Fund , Biological Engineering , Miles Huseyin , Massachusetts Medical School , Region Capture Micro C , Boston Children , Koch Institute Support , National Institutes ,

An unprecedented view of gene regulation

Using a new technique, MIT researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible. ....

University Of Massachusetts Medical School , United States , Stanley Hsieh , Christine Eyler , Anders Sejr Hansen , Oliver Rando , Umass Medical School , Koch Institute , National Cancer Institute , Solomon Buchsbaum Research Support Committee Award , Koch Institute Frontier Research Fund , National Science Foundation , University Of California At Berkeley , Harvard Medical School , Duke University School Of Medicine , National Institutes Of Health , Biological Engineering , Miles Huseyin , Massachusetts Medical School , Region Capture Micro C , Boston Children , Duke University School , Koch Institute Support , National Institutes , D Genome Structure , Gene Regulation ,