<p>Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge - especially in living cells, as the required fluorescent labelling had to be individually attached to each protein. The research group led by Stefan Kubicek at CeMM has now overcome this hurdle: With a method called "vpCells," it is possible to label many proteins simultaneously, using five different fluorescent colours. This automated high-throughput approach, aided by AI-assisted image recognition, opens up entirely new applications in various disciplines, from fundamental cell biology to drug discovery. The study has been published in the journal <em>Nature Cell Biology</em> (DOI: 10.1038/s41556-024-01407-w), and the related images are available at <em>vpcells.cemm.at</em>.</p>