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Common anti-depressant may be first-ever treatment for osteoarthritis Researchers found that Paroxetine not only slows down cartilage degeneration, but also promotes cartilage health in both mice and human cartilage in vitro. Image: Fadia Kamal, Penn State Common anti-depressant may be first-ever treatment for osteoarthritis Sara LaJeunesse February 10, 2021 HERSHEY, Pa. A disease of the joints, osteoarthritis affects more than 30 million adults and is the fifth-leading cause of disability in the United States. In a new study, scientists have discovered the cellular pathway that leads to osteoarthritis and have identified a commonly used anti-depressant paroxetine that inhibits this pathway. The team found that Paroxetine not only slows down cartilage degeneration, but also promotes cartilage health in both mice and human cartilage in vitro. The drug may be the first-ever treatment for this debilitating, degenerative disease.

United statesEric schottReyad elbarbaryMichael zuscikHadeel ahmadVengadeshprabhu karuppagounderFadia kamalHeather le bleuElijah carlsonNatalie yoshiokaWilliam pinamontArthritis national research foundationUniversity of colorado anschutz medical campusNational institutes of healthPenn state college of medicineBarsumian foundation fund