The children it supports have faced numerous challenges from a reduction in their usual support services and therapies to changes in routine, being isolated at home, and homeschooling.
The pandemic has also hit family finances as job losses or reduced hours take their toll, particularly for those with a disabled child who outgoings are on average £600 a month higher than other families.
The campaign is backed by Mr Knowles, Olympic stars Jane Torvill and Christopher Dean, Eamonn Holmes, Heather Small and Lorraine Kelly.
The aim is to encourage the nation to keep passing on the acts of kindness that flourished during the past year and help Variety’s work with disabled and disadvantaged children by sharing photos and videos and raising much needed donations.