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Study Finds Tar-Like Peptides Block Nucleic Acids, Leading to Motor Neuron Death in Familial ALS

Study Finds Tar-Like Peptides Block Nucleic Acids, Leading to Motor Neuron Death in Familial ALS
May 12, 2021
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Research by scientists at the Spanish National Cancer Research Centre (CNIO) has uncovered a mechanism that may explain what causes neuronal cell death in cases of amyotrophic lateral sclerosis (ALS) that are associated with mutations in a gene known as C9ORF72. The findings suggest that the C9ORF72 gene mutations are toxic because they induce the cell to produce small proteins or peptides that are very rich in arginine, an amino acid that, due to its positive charge and chemical nature, binds very avidly to nucleic acids, including DNA and RNA. The resulting peptides stick to the DNA “like a kind of tar,” effectively blocking them from their normal interactions with other proteins, and disrupting fundamental cell processes. ....

Vanesa Lafarga , Jack Szostak , Spanish National Cancer Research Centre , Genomic Instability Group , Instability Group , பலா ஸ்ஜோஸ்த்தக் , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் ,

CNIO researchers explain the toxicity of USP7 inhibitors, under development for cancer treatment

Credit: CNIO
Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer. It was precisely the discoveries of key regulators of the cell cycle and their implications for processes such as cancer, that won the British scientists R. Timothy Hunt and Paul M. Nurse and the American scientist Leland H. Hartwell the 2001 Nobel Prize in Physiology or Medicine. A study led by Óscar Fernández-Capetillo, Head of the Genomic Instability Group at the Spanish National Cancer Research Centre (CNIO) and published this week in ....

United States , United Kingdom , Lelandh Hartwell , Marcos Malumbres , Emilio Lecona , Oscar Fernandez Capetillo , Vanesa Lafarga , Antonio Galarreta , Pablo Valledor , Patricia Ubieto , European Regional Development Fund , Spanish National Cancer Research Centre , Spanish Ministry Of Science , Head Of The Genomic Instability Group , European Research Council , Institute Of Health , Genomic Instability Group , Nature Structural , Molecular Biology , Spanish Ministry , European Regional Development , Biomedical Environmental Chemical Engineering , Molecular Biology , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் ,