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Dr Van Tine on Investigating Cabozantinib With PD-1 and CTLA-4 Inhibition in Sarcoma

Brian A. Van Tine, MD, PhD, discusses the rationale for launching a randomized phase 2 trial investigating cabozantinib combined with nivolumab and ipilimumab vs cabozantinib alone in metastatic soft tissue sarcoma and discusses key findings from the trial.
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Briana Van , Division Of Oncology , Washington University School Of Medicine , Siteman Cancer Center , Medical Oncology , Washington University School , Van Tine , Washington University School Of Medicine In St Louis , Onclive Tv ,

Dr Van Tine on the Investigation of KB-0742 in R/R Solid Tumors

Brian A. Van Tine, MD, PhD, discusses the ongoing evaluation of the CDK9 inhibitor KB-0742 in a phase 1 trial in patients with relapsed/refractory solid tumors or non-Hodgkin lymphoma, detailing the key enrollment criteria.
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Briana Van , Siteman Cancer Center , Division Of Oncology , Washington University School Of Medicine , Medical Oncology , Washington University School , Van Tine , Research Underway For Myc Amplified Relapsed Or Refractory Solid Tumors , Onclive Tv ,

1930-present: Labour unrest and the successive geographical restructuring of the world automobile industry - Beverly Silver

Beverly Silver traces the growth of workers power in the auto industry and the resultant outsourcing of industry to lower wage areas of the globe, where workers organised again and fought for better conditions, effectively spreading a militant workers' movement across the globe. ....

Indiana University , United States , Sao Bernardo Do Campo , Great Lakes , United Kingdom , Sao Bernardo , South Korea , France General , New York , New Horizons , Western Cape , South Africa , Columbia University , San Francisco , Port Elizabeth , Eastern Cape , Sao Paulo , White House , District Of Columbia , Central Bedfordshire , City Of , Beverly Hills , Ch Ungch Ong Namdo , Barking And Dagenham , Soult Ukpyolsi , Maria Helena ,

Auchampaugh: The migration to Owasco and Fleming 230 years ago

On April 30, 1793 — 230 years ago this week — a wagon train left the Dutch settlement called Conewango, Pennsylvania, and traveled to “The Lake Country of New York." ....

United States , Dutch Church , New York , Owasco Lake , Dutch Hollow Brook , Cherry Valley , Albert Demerest , Daniel Boone , Isaac Parsell , George Washington , Jacob Loyster , Abraham Bodine , Richard Parsell , Timothy James Brinkerhoff , Jacob Brinkerhoff , Thomas Johnson , Andrew Johnson , George Brinkerhoff , Cornelius Bodine , Roeliff Brinkerhoff , Cornelius Cozine , Albert Demorest , Luke Brinkerhoff , Dutch Reformed Church , Conewago Reformed Church , Clinton Sullivan Campaign ,

Pembrolizumab Monotherapy Effective for Rare Melanoma

Pembrolizumab led to a dramatic overall response rate among patients with unresectable desmoplastic melanoma. ....

United States , Bristol Myers Squibb , Kari Kendra , Zeynep Aroglu , Ohio State University Wexner Medical Center , Boehringer Ingelheim , Washington University In St , Varian Medical Systems , Checkmate Pharmaceuticals , American Association For Cancer Research , American Association , Brian Van Tine , Washington University , Varian Medical , Van Tine , Malignant Melanoma , Skin Cancer , Alignant Skin Neoplasm , Biologic Therapy , Alignant Neoplasia , Neck Cervical Region Of , Elderly Concerns Of Older Adults , Cutaneous Melanoma , Geriatrics Elder Care , Neurofibromatosis Type 1 , Eurofibromatosis Typei Nf 1 ,