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CureVac, GSK Begin Clinical Trial For Second-Generation COVID-19 Vaccine Candidate, CV2CoV

LONDON (dpa-AFX) - German biopharmaceutical company CureVac N.V. (CVAC) announced Wednesday that the first participant was dosed in a Phase 1 study of COVID-19 second-generation mRNA vaccine candidate

DGAP-News: CureVac: mRNA-basierter COVID-19-Impfstoffkandidat der zweiten Generation, CV2CoV, zeigt verbesserte Immunantwort und Schutzwirkung in präklinischer Studie

GSK, CureVac s next-gen COVID-19 jab generates positive preclinical data

GSK, CureVac’s next-gen COVID-19 jab generates positive preclinical data 14th May 2021 GlaxoSmithKline (GSK) and CureVac’s second generation COVID-19 vaccine, CV2CoV, has generated positive preclinical data, the companies announced yesterday. Preclinical testing in a rat model showed that CV2CoV induces high levels of antigen production and strong, dose-dependent immune responses in vaccinated animals. The data, published on the pre-print server bioRxiv, also showed that rats immunised with the second-generation jab demonstrated ‘fast onset’ of strong immune responses after their first dose. On top of that, the serum of vaccinated animals showed significant cross-neutralisation against variants of concern, including those first discovered in Denmark (B.1.1.298), the UK (B.1.1.7) and South Africa (B.1.351).

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