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Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization
Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body s glucose levels, which is important for the development of metabolic diseases like diabetes.
In a recent study, published in
The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat.
In the study, Mukesh K. Jain, MD, senior author, Chief Academic Officer at UH, and the Ellery Sedgwick Jr. Chair & Distinguished Scientist, and his team set out to investigate the role of a gene called Kruppel-like factor 15 (KLF15) in skeletal muscle. The team utilized a mouse model with KLF15 specifically ....

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