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Angela Koehler takes on the most challenging drug targets

Angela Koehler, an associate professor of biological engineering at MIT, has made it her mission to find ways to drug “undruggable” targets. By taking aim at proteins that interact with these targets, she can indirectly disable them or reduce their impact. ....

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Terremoto spells out covalent drug alphabet with $75M series A

Terremoto Biosciences will use $75 million in series A funding to broaden the covalent drug alphabet available to treat complex diseases. ....

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HitGen and UPPTHERA Extend PROTAC Research Collaboration after Hit Finding Success on Undruggable Targets | More News

HitGen and UPPTHERA Extend PROTAC Research Collaboration after Hit Finding Success on Undruggable Targets ....

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Aum bags $27M to hit cancer targets pursued by Bayer, Roche

Aum Biosciences is moving on to oncology turf targeted by companies including Bayer and Roche, securing $27 million to take inhibitors of MNK and TRK into midphase clinical trials. ....

Aum Biosciences , Roche Rozlytrek , Bayer Vitrakvi , Effector Therapeutics , Venture Capital Vc , Argeted Cancer Drugs , Undruggable Targets , Drug Resistance ,

Novel protein degrader against 'undruggable' cancer target inhibits tumors in mice

Riding a growing interest in protein degradation, researchers at the Indiana University School of Medicine identified a small-molecule degrader for a cancer-promoting target called SUMO1, which was previously considered "undruggable." The compound inhibited tumor growth in mouse models of human breast, colon and lung cancers being developed by startup HB Therapeutics. ....

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