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Scientists 'farm' natural killer cells in novel cancer fighting approach

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IMAGE: Two large natural killer immune cells are surrounded by their much smaller exosomes on the NK-GO microfluidic chip developed at the University of Michigan.
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Credit: Image courtesy of Yoon-Tae Kang and Zeqi Niu.
Building on the promise of emerging therapies to deploy the body s natural killer immune cells to fight cancer, researchers at the University of Michigan Rogel Cancer Center and U-M College of Engineering have gone one step further.
They ve developed what is believed to be the first systematic way to catch natural killer cells and get them to release cancer-killing packets called exosomes. These nano-scale exosomes are thousands of times smaller than natural killer cells or NK cells for short and thus better able to penetrate cancer cells defenses. ....

United States , Gemma Purcell , Venkateshwarg Keshamouni , Sunitha Nagrath , Nithya Ramnath , Thomas Hadlock , Rishindra Reddy , Sarah Owen , Zeqi Niu , Mina Zeinali , Labyrinth Biotech Inc , National Institute Of Health , Rogel Cancer Center , National Science Foundation , Um College Of Engineering , University Of Michigan , Microfluidic Labyrinth Technology , Um Biointerfaces Institute , University Of Michigan Rogel Cancer Center , Michigan Rogel Cancer Center , Gum College , Yoon Tae Kang , Rogel Cancer , National Institute , Um Biointerfaces , Labyrinth Biotech ,

How to end discrimination in health research funding

Mario Gutierrez consults Prof. Lola Eniola while using fluorescent microscopy to study the effect of red blood rigidification on the thermodynamics of blood flow. Graduate students and post-docs work at Prof. Lola Eniola’s Cell Adhesion & Drug Delivery Lab in North Campus Research Complex. Image credit: Marcin Szczepanski/Multimedia Director and Senior Producer, University of Michigan, College of Engineering
White researchers are nearly twice as likely to be awarded a grant than Black scientists of similar academic achievement, studies of National Institutes of Health funding programs show and a group of 19 biomedical engineering leaders is calling on NIH and other funding agencies to address the stark disparity. ....

United States , Elizabeth Cosgriff Hernandez , Tejal Desai , Stacey Finley , Mario Gutierrez , Kelly Stevens , Lola Eniola , Karen Christman , Abigail Koppes , Joyce Wong , Naomi Chesler , Shelly Sakiyama Elbert , Lori Setton , Josephine Allen , Hana El Samad , Rebecca Willits , Omolola Eniola Adefeso , Karmella Haynes , Padmini Rangamani , Muyinatu Lediju Bell , Johns Hopkins University , Campus Research , Emory University , University Of California Irvine , University Of Florida , College Of Engineering Mario Gutierrez ,