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Researchers target 'Jekyll and Hyde' bacteria behind respiratory infections

Researchers have discovered a way to kill a type of bacteria that causes millions of respiratory infections in children and the elderly, paving the ....

Jennifer Hosmer , Ulrike Kappler , University Of Queensland , Uq School Of Chemistry , Haemophilus Influenzae , Professor Ulrike Kappler , Molecular Biosciences ,

Tiny amino acid differences can lead to dramatically different enzymes


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IMAGE: By slightly adjusting an enzyme s amino acids, it can live in completely different environments.
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Credit: Dr Ulrike Kappler
Just a few changes to an enzyme s amino acids can be enough to dramatically change its function, enabling microbes to inhabit wildly different environments.
University of Queensland microbiologist Associate Professor Ulrike Kappler, led by an international team of researchers, made this discovery when investigating how Haemophilus influenzae bacteria colonise the human respiratory system.
This disease-causing bacterium is supremely adapted to living in humans, so much so that they cannot survive anywhere else, Dr Kappler said.
It turns out that one enzyme, MtsZ, is the key player in this adaptation. ....

United States , Ulrike Kappler , University Of Queensland , Associate Professor Ulrike Kappler , Biological Chemistry , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து , உயிரியல் வேதியியல் ,