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Ryan zarychanskiAlistair nicholEwan goligherAlistair nicholsaidUniversity of torontoIrish critical care clinical trials networkUcd school of medicineHealth research boardIntensivist at st vincent university hospitalAdaptive platform trial for communityNew england journalAssociate professorInternal medicineCancercare manitobaTherapeutic anticoagulationAntithrombotic therapy