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New AI model sets benchmark in digital pathology with superior cancer diagnostics

Researchers developed Prov-GigaPath, a whole-slide pathology foundation model using a novel vision transformer architecture. The model demonstrates superior performance in mutation prediction, cancer subtyping, and vision-language tasks. It leverages large-scale real-world data from over 30,000 patients to enhance clinical diagnostics. ....

Convolutional Neural Network , Long Sequence Network Longnet , Providence Gigapixel Pathology Model , Vision Transformer , Long Sequence Network , Hierarchical Image Pyramid Transformer , Contrastive Learning Based Pathology Model , Data Efficient Generalization , Self Supervised Machine Learning , Diagnostic Imaging , Cancer Genome Atlas , Simple Framework , Contrastive Learning , Visual Representations , Attention Based Multiple Instance Learning , Providence Pathology , Pan Tumor Cancer , Area Under , Receiver Operating Characteristic Curve , Precision Recall Curve , Generative Pre Trained Transformer , Multiple Instance Learning Zero Shot Transfer , Pathology Specific Language Image Pre Training , Lung Adenocarcinoma , Tumor Mutation Burden , Non Small Cell Lung Cancer ,

XRCC1 shows potential as a prognostic and immunological pan-cancer biomarker

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, "XRCC1: a potential prognostic and immunological biomarker in LGG based on systematic pan-cancer analysis." ....

Luling Huang , Rui Pan , Guobing Wang , Gang Tian , Yunyue Li , Congchao Jia , Guanhu Yang , Hao Chi , Ohio University , Hospital Of Southwest Medical University , Fourth Military Medical University , School Of Nanchang University , Xisheng Yin , Yuchen She , Southwest Medical University , Affiliated Hospital , Yibin Hospital , Medical School , Nanchang University , Tumor Mutation Burden , Microsatellite Instability , Human Protein Atlas , Ene Expression , X Ray ,

XRCC1: Prognostic and Immunological Tool in Low-Grade Gliomas

XRCC1: Prognostic and Immunological Tool in Low-Grade Gliomas
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Guobing Wang , Yunyue Li , Luling Huang , Gang Tian , Congchao Jia , Guanhu Yang , Rui Pan , Hao Chi , Hospital Of Southwest Medical University , Ohio University , Fourth Military Medical University , School Of Nanchang University , Xisheng Yin , Yuchen She , Southwest Medical University , Affiliated Hospital , Yibin Hospital , Medical School , Nanchang University , Tumor Mutation Burden , Microsatellite Instability , Human Protein Atlas ,

XRCC1: A potential prognostic and immunological biomarker in low-grade gliomas

XRCC1: A potential prognostic and immunological biomarker in low-grade gliomas
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Guobing Wang , Tumor Mutation Burden , Microsatellite Instability , Human Protein Atlas ,

"Comparing Genomic Landscapes of Oral and Cutaneous Squamous Cell Carci" by Ruta Gupta, Dario Strbenac et al.

Squamous cell carcinoma is the most common head and neck malignancy arising from the oral mucosa and the skin. The histologic and immunohistochemical features of oral squamous cell carcinoma (OSCC) and head and neck cutaneous squamous cell carcinoma (HNcSCC) are similar, making it difficult to identify the primary site in cases of metastases. With the advent of immunotherapy, reliable distinction of OSCC and HNcSCC at metastatic sites has important treatment and prognostic implications. Here, we investigate and compare the genomic landscape of OSCC and HNcSCC to identify diagnostically useful biomarkers. Whole-genome sequencing data from 57 OSCC and 41 HNcSCC patients were obtained for tumor and matched normal samples. Tumor mutation burden (TMB), Catalogue of Somatic Mutations in Cancer (COSMIC) mutational signatures, frequent chromosomal alterations, somatic single nucleotide, and copy number variations were analyzed. The median TMB of 3.75 in primary OSCC was significantly lower (P ....

Somatic Mutations , Head And Neck , Eratinizing Squamous Cell Carcinoma , Utation Signature , Tumor Mutation Burden , Whole Genome Sequencing ,