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04.23.21 -- Improved Bioavailability In 12 Weeks


04.23.21 Improved Bioavailability In 12 Weeks
 
 
An orally disintegrating tablet (ODT) is designed to rapidly dissolve on contact with saliva. This webinar presents the Zydis® ODT technology, a unique freeze-dried tablet, and introduces Zydis Ultra, which incorporates coated APIs for enhanced taste masking at a higher dose strength.
 
When Trio Medicines’ lead compound showed clinical promise but had limited bioavailability owing to low solubility, an integrated platform with a structured three-step approach substantially enhanced the bioavailability with a limited budget in a tight timeframe.
 
In this case study, a quality by design (QbD) approach was used to solve a high-performance liquid chromatography (HPLC) analytical method problem where impurity peaks had shifting retention times, making identification and quantitation problematic. ....

Zydis Ultra , Trio Medicine ,

04.21.21 -- Improved Bioavailability In 12 Weeks


04.21.21 Improved Bioavailability In 12 Weeks
 
 
An orally disintegrating tablet (ODT) is designed to rapidly dissolve on contact with saliva. This webinar presents the Zydis® ODT technology, a unique freeze-dried tablet, and introduces Zydis Ultra, which incorporates coated APIs for enhanced taste masking at a higher dose strength.
 
When Trio Medicines’ lead compound showed clinical promise but had limited bioavailability owing to low solubility, an integrated platform with a structured three-step approach substantially enhanced the bioavailability with a limited budget in a tight timeframe.
 
In this case study, a quality by design (QbD) approach was used to solve a high-performance liquid chromatography (HPLC) analytical method problem where impurity peaks had shifting retention times, making identification and quantitation problematic. ....

Zydis Ultra , Trio Medicine ,