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BerGenBio Announces Update From Investigational Phase II Trials Assessing Bemcentinib In Hospitalised COVID-19 Patients


BerGenBio Announces Update From Investigational Phase II Trials Assessing Bemcentinib In Hospitalised COVID-19 Patients
Data receipt is ongoing and evaluation of efficacy data is underway
Exploratory analyses are looking to define subsets of patients with baseline markers indicative of increased disease severity with the potential for greater benefit
Bemcentinib was well tolerated throughout both studies, in the ACCORD2 study there was a numerically lower number of deaths up to day 29 in the bemcentinib arm (1 of 28 with bemcentinib + standard of care vs 5 of 32 in patients treated with standard of care alone); in BGBC020 it was 2 vs 3 respectively
More detailed top line data expected to report in May ....

South Africa , United Kingdom , Chris Welsh , Carina Jurs , Mary Jane Elliott , Richard Godfrey , Prnewswire Bergenbio , Tom Wilkinson , Lucy Featherstone , International Media Relations , Consilium Strategic Communications , Oslo Stock Exchange , Professor Tom Wilkinson , Respiratory Medicine , Chief Investigator , Chief Executive Officer , Trial Synopsis , Jane Elliott , Petter Stiff , Crux Advisers , Norwegian Securities Trading , ஒன்றுபட்டது கிஂக்டம் , கிறிஸ் வெல்ஶ் , கரினா ஜூர்ஸ் , மேரி ஜேன் எலியட் , ரிச்சர்ட் காட்ஃப்ரே ,

BerGenBio Announces Update From Investigational Phase II Trials Assessing Bemcentinib In Hospitalised COVID-19 Patients


Data receipt is ongoing and evaluation of efficacy data is underway
Exploratory analyses are looking to define subsets of patients with baseline markers indicative of increased disease severity with the potential for greater benefit
Bemcentinib was well tolerated throughout both studies, in the ACCORD2 study there was a numerically lower number of deaths up to day 29 in the bemcentinib arm (1 of 28 with bemcentinib + standard of care vs 5 of 32 in patients treated with standard of care alone); in BGBC020 it was 2 vs 3 respectively
More detailed top line data expected to report in May
BERGEN, Norway, April 19, 2021 /PRNewswire/  BerGenBio ASA (OSE:BGBIO), a clinical-stage biopharmaceutical company developing novel, selective AXL kinase inhibitors for severe unmet medical need, provides an update from the Phase II clinical study evaluating the efficacy and safety of bemcentinib in hospitalised COVID-19 patients (BGBC020). ....

South Africa , United Kingdom , Chris Welsh , Mary Jane Elliott , Richard Godfrey , Jan Petter , Tom Wilkinson , Lucy Featherstone , Strategic Communications , International Media Relations , Oslo Stock Exchange , Professor Tom Wilkinson , Respiratory Medicine , Chief Investigator , Chief Executive Officer , Trial Synopsis , Media Relations , Jane Elliott , Crux Advisers , Norwegian Securities Trading , Bergenbio Asa , ஒன்றுபட்டது கிஂக்டம் , கிறிஸ் வெல்ஶ் , மேரி ஜேன் எலியட் , ரிச்சர்ட் காட்ஃப்ரே , டோம் வில்கின்சன் ,

DGAP-News: Immunic, Inc. Announces That Oral Treatment IMU-838 Shows Evidence of Clinical Activity in Moderate COVID-19 in Phase 2 CALVID-1 Trial


DGAP-News: Immunic, Inc. Announces That Oral Treatment IMU-838 Shows Evidence of Clinical Activity in Moderate COVID-19 in Phase 2 CALVID-1 Trial
Table: IMU-838 Shows Acceleration of Time to Clinical Improvement
High-risk patients and patients aged over 65 years experienced a more substantial treatment benefit from IMU-838 than in the general patient population:
- The 75% probability
[5] to reach clinical improvement (based on investigator assessment) was accelerated by 3.8 days in IMU-838 treated high-risk patients
[6], as compared to placebo (FAS).
- The 75% probability
[5] to reach clinical improvement (based on investigator assessment) was accelerated by 4.8 days in IMU-838 treated elderly patients (65 years or older), as compared to placebo (FAS). ....

United States , Paula Schwartz , Edna Kaplan , Jessica Breu , Andreas Muehler , Daniel Vitt , Exchange Commission , World Health Organization , Rx Communications Group , Immunic Inc , Distribution Services , Announces That Oral Treatment , Clinical Activity , Multiple Secondary Endpoints , Including Clinically Meaningful Improvements , Clinical Recovery , Clinical Improvement , Very Low Rates , Serious Complications , Hospitalized Patients With Moderate , Risk Patients , Patients Aged Over , More Substantial Treatment Effect , Anti Inflammatory Effect Observed , More Effective Reduction , C Reactive Protein ,