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GP-delivered medication review of polypharmacy, deprescribing, and patient priorities in older people with multimorbidity in Irish primary care (SPPiRE Study): A cluster randomised controlled trial

Caroline McCarthy and colleagues investigate the effect of a general practitioner-delivered, individualized medication review on polypharmacy and potentially inappropriate prescribing in community dwelling older patients with multimorbidity in Irish primary care.

Patients With Opioid Dependence Prefer Depot vs Sublingual Buprenorphine

Subcutaneous depot buprenorphine led to better treatment satisfaction compared with sublingual buprenorphine in patients with opioid dependence.

Long-Acting Opioid Use Disorder Treatment Brings Better Response

May 12, 2021 Patients report greater satisfaction with weekly, monthly buprenorphine People with opioid dependence reported being more satisfied and more compliant with weekly or monthly depot buprenorphine versus sublingual buprenorphine, researchers reported. In an open-label, 24-week randomized trial done at six outpatient clinical sites in Australia, the self-reported global satisfaction score was significantly higher for the depot group compared with the sublingual group at a mean TSQM (Treatment Satisfaction Questionnaire for Medication v1.4) score of 82.5 versus 74.3, for a difference of 8.2 (95% CI 1.7-14.6, P=0.01), according to Fredrik Tiberg, PhD, of Camurus in Lund, Sweden, and co-authors (TQSM ranges from 0-100 with higher score indicating greater satisfaction).

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