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Study shows adaptive brain response to stress, and its absence in people with depression


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A new study identifies a novel biomarker indicating resilience to chronic stress. This biomarker is largely absent in people suffering from major depressive disorder, and this absence is further associated with pessimism in daily life, the study finds.
Nature Communications published the research by scientists at Emory University.
The researchers used brain imaging to identify differences in the neurotransmitter glutamate within the medial prefrontal cortex before and after study participants underwent stressful tasks. They then followed the participants for four weeks, using a survey protocol to regularly assess how participants rated their expected and experienced outcomes for daily activities. ....

United States , Makiah Nuutinen , Daniel Cole , Michael Treadway , Shabnam Hossein , Brittany Devries , Gemma Hahn , Chelsea Leonard , Jessica Cooper , Nature Communications , Emory University , Treadway Translational Research In Affective Disorders Laboratory , Kaiser Family Foundation , Department Of Psychiatry , National Institutes Of Mental Health , Mclean Hospital Harvard Medical School , Emory Department Of Psychology , University Of Arkansas , Translational Research , Affective Disorders , Kaiser Family , Victoria Lawlor , Andrew Teer , Harvard Medical , National Institutes , Medicine Health ,

Depressed brains don't have the regular response to stress


A new study identifies a novel biomarker indicating resilience to chronic stress.
This biomarker is largely absent in people suffering from major depressive disorder, and this absence is further associated with pessimism in daily life, the study finds.
Researchers used brain imaging to identify differences in the neurotransmitter glutamate within the medial prefrontal cortex before and after study participants underwent stressful tasks. They then followed the participants for four weeks, using a survey protocol to regularly assess how participants rated their expected and experienced outcomes for daily activities.
“In many ways, depression is a stress-linked disorder.”
“To our knowledge, this is the first work to show that glutamate in the human medial prefrontal cortex shows an adaptive habituation to a new stressful experience if someone has recently experienced a lot of stress,” says senior author Michael Treadway, professor in Emory University’s depar ....

United States , Michael Treadway , Jessica Cooper , Nature Communications , Emory University Department , Princeton University , Treadway Translational Research In Affective Disorders Laboratory , Kaiser Family Foundation , National Institutes Of Mental Health , Mclean Hospital Harvard Medical School , University Of Arkansas , Emory University , Translational Research , Affective Disorders , Kaiser Family , Harvard Medical , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , மைக்கேல் நடைபாதை , ஜெசிகா கூப்பர் , இயற்கை தகவல்தொடர்புகள் , உணர்ச்சி பல்கலைக்கழகம் துறை , ப்ரிந்ஸ்டந் பல்கலைக்கழகம் , கைசர் குடும்பம் அடித்தளம் , தேசிய நிறுவனங்கள் ஆஃப் மன ஆரோக்கியம் , மக்லீந் மருத்துவமனை ஹார்வர்ட் மருத்துவ பள்ளி ,