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Regulation of seed oil accumulation by lncRNAs in Brassica napus | Biotechnology for Biofuels and Bioproducts

Studies have indicated that long non-coding RNAs (lncRNAs) play important regulatory roles in many biological processes. However, the regulation of seed oil biosynthesis by lncRNAs remains largely unknown. We comprehensively identified and characterized the lncRNAs from seeds in three developing stages in two accessions of Brassica napus (B. napus), ZS11 (high oil content) and WH5557 (low oil content). Finally, 8094 expressed lncRNAs were identified. LncRNAs MSTRG.22563 and MSTRG.86004 were predicted to be related to seed oil accumulation. Experimental results show that the seed oil content is decreased by 3.1–3.9% in MSTRG.22563 overexpression plants, while increased about 2% in MSTRG.86004, compared to WT. Further study showed that most genes related to lipid metabolism had much lower expression, and the content of some metabolites in the processes of respiration and TCA (tricarboxylic acid) cycle was reduced in MSTRG.22563 transgenic seeds. The expression of genes involved in

Non coding indexCoding potential calculatorCoding potential assessment toolFalse discovery rateTransposase accessible chromatin

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation
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Cleavage under targetsBecause tetTransposase accessible chromatin

Biomarker Predicts Nonresponse to CAR T in Pediatric ALL

Alternative strategies could be offered to children and young adults with advanced acute lymphoblastic leukemia (ALL) identified as being unlikely to respond to the expensive therapy.

United statesUnited kingdomNew jerseyJaved khanMaria lopezKatherinee masihJefferson health new jerseyNational cancer instituteSidney kimmel cancer centerGenetics branchCancer researchAmerican association for cancer researchBaldrick foundationSeattle children research instituteCambridge scholars programAmerican association

Chromatin accessibility as an early marker of severe COVID-19

A new study explores the possible use of chromatin remodeling in predicting a severe clinical trajectory for COVID-19.

Research squareScientific reportsDifferential chromatin accessibilityPeripheral blood mononuclear cells underliesImage creditTransposase accessible chromatinMolecular epidemiological studySuspected infectionCoronavirus disease covid 19Ene expressionImmune responseInterleukin 6Ars cov 2Evere acute respiratoryEvere acute respiratory syndromeTranscription factors

Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia
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United statesTransposase accessible chromatinRelated geneSuper enhancer