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ESR1 Coalteration Treatment Resistance Does Not Impact Lasofoxifene/Abemaciclib Efficacy in ESR1+ Metastatic Breast Cancer

The presence of ESR1 coabnormalities, including TP53 and PIK3CA mutations, and CCND1 and FGFR1 amplification, did not demonstrate a negative impact on the efficacy with lasofoxifene and abemaciclib in patients with estrogen receptor–positive, ESR1-mutant metastatic breast cancer.
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San Antonio , United States , Dsenthil Damodaran , University Of Texas Md Anderson Cancer Center , Antonio Breast Cancer Symposium , Cancer Center , Metastatic Breast Cancer , Breast Cancer , San Antonio Breast Cancer Symposium , Phase 2 Elaine Study , Esr1 Coalteration , Tp53 And Pik3ca , Estrogen Receptor Positive ,