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Long-acting GIPRA inhibits feeding and lowers body weight in mice with diet-induced obesity

The hormone glucose-dependent insulinotropic polypeptide (GIP) is considered obesogenic. In contrast, GIP receptor agonists (GIPRAs) have shown reduced feeding and body weight in an obese mouse model. Therefore, the precise effects exerted by GIP and GIPRAs remain elusive. ....

Japan General , Toshihiko Yada , Wanxin Han , Daisuke Yabe , Yutaka Seino , Emily Henderson , Gifu University Graduate School Of Medicine , Kansai Electric Power Medical Research Institute , Medicine Innovative Translational Research , Gifu University Graduate School , Gifu University , Graduate School , One Medicine Innovative Translational Research , Kansai Electric Power , Industry Focus , Central Nervous System , Glp 1 , Medical Research , Ouse Model , Nervous System , Small Intestine , Type 2 Diabetes ,