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Predicting drug absorption in miniatured human liver


Kyoto University
The Kazuo Takayama lab reports that PDMS-based liver-on-chip naturally absorb some drugs, which affects drug toxicity results.
Liver-on-a-chip are miniaturized devices that capture the physiological and mechanical properties of the liver. They are commonly used by researchers to study how the liver metabolizes different compounds and drugs. In a new study seen in ACS Biomaterials Science & Engineering, CiRA Junior Associate Professor Kazuo Takayama and colleagues report which drugs based on their physicochemical properties are most suitable when using liver-on-a-chip to study drug toxicity.
One of the most important tests for any drug approval is hepatotoxicity. In fact, the United States Food and Drug Administration claims it is the number one cause of safety-related drug withdrawal from the market. Thus, exhaustive testing is mandatory, as otherwise a company that has invested billions of dollars on a drug could see it all lost because of ....

United States , Emi Sano , Fumiyoshi Yamashita , Ryosuke Negoro , Hiroyuki Mizuguchi , Kazuo Takayama , Kaori Osugi , Ayaka Sakamoto , Natsumi Mimura , Kazuya Maeda , Sayaka Deguchi , Masahiro Tsuda , Hiroyuki Kusuhara , Ritsumeikan University , Laboratory Of Molecular Pharmacokinetics , Ps Cell Research , Department Of Clinical Application , Kyoto University , Department Of Drug Delivery Research , Drug Administration , School Of Pharmaceutical Sciences , Department Of Micro Engineering , Laboratory Of Biochemistry , College Of Pharmaceutical Sciences Department , Osaka University , Department Of Applied Pharmaceuticals ,

Japan travel guide and things to do: 32 gold medal experiences


The Games of the 32nd Olympiad are here. One of the world s greatest sporting events in one of the world s greatest cities. It doesn t get much better than that.
This will be a time for athletes and for sports, of course. But it will also be an opportunity not just for Tokyo but for Japan as a whole to showcase its attractions, to demonstrate to the world what it can do, what it can offer, and why the country s tourism industry was booming until COVID-19 slammed on the brakes.
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Japan has so many drawcards for visitors, from cities to nature, tradition to modernity, food to sport, culture to physical beauty. It has famous attractions and it has those that are flying under the radar. It s the perfect destination for pleasure-seekers, for thrill-seekers, for history buffs, for creatives, for gourmands. ....

Japan General , Kii Peninsula , Shiga Kogen , Isshobin Yakiniku , Donald Trump , Kokusekiji Sominsai , Kanda Matsuri , Hidenori Iwasaki , Sukayu Onsen , Louise Southerden , Kumano Kodo , Brian Johnston , Mt Haguro , David Poller , Saikan Sanroshu , Kiichiro Sato , Ben Groundwater , Shinzo Abe , Omoide Yokocho , Akie Abe , Ben Fiddich , Tokyo Metropolitan Art Museum , Yayoi Kusama Museum , Japan National Treasures , Studio Ghibli Museum , Capitol Hotel Tokyu ,