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cnn s randi kaye has details of their story. my friend and mentor, oprah winfrey! reporter: long before dr. mehmet oz got his own show, he was a regular on opera s talk show making more than 60 appearances. all these chemicals, they just are going up. it s fight or flight. something s coming at you and you can either fight it or run. reporter: he held oprah s hand on tv the first time she got acupuncture. as these needles go in, they re going to get placed at your nerve, as these nerves get stimulated. when are they going in? not yet. reporter: and awed her audience with spell binding demonstrations. this is a female heart, you get to hold that one. it s about the size of your fist. and this is the male heart. reporter: oz appeared on the show from 2006 to 2011 during which the harvard educated heart surgeon became a household name. i want to challenge you all. reporter: in 2009, oprah s company launched the dr. oz show. it s like my son grew up.

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