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How does a family history of psychosis influence the risk of methamphe by Rebecca McKetin, Philip J Clare et al

Aims: To determine whether the risk of psychotic symptoms during weeks of methamphetamine use was dependent on, increased by, or independent of having a family history of psychosis. Design: Secondary analysis of 13 contiguous 1-week periods of data (1370 weeks). A risk modification framework was used to test each scenario. Setting: Geelong, Wollongong and Melbourne, Australia. Participants: Participants in a randomized controlled trial of treatment for methamphetamine dependence (n = 148) who did not have a primary psychotic disorder on enrolment. Measurements: Psychotic symptoms in the previous week were defined as a score of 3+ on any of the Brief Psychiatric Rating Scale items of hallucinations, unusual thought content or suspiciousness. Any (vs no) methamphetamine use in the previous week was assessed using the Timeline Followback method. Self-reported family history of psychosis was assessed using the Diagnostic Interview for Psychosis. Findings: The risk of psychotic symptoms in

WKU faculty member gets grant for more than $400,000 to continue substance use research

Clinical and demographic characteristics of people who smoke versus in by Rebecca McKETIN, Brendan Quinn et al

Introduction and Aims: There has been a rapid increase in smoking crystalline methamphetamine in Australia. We compare the clinical and demographic characteristics of those who smoke versus inject the drug in a cohort of people who use methamphetamine. Design and Methods: Participants (N = 151) were dependent on methamphetamine, aged 18–60 years, enrolled in a pharmacotherapy trial for methamphetamine dependence, and reported either injecting (n = 54) or smoking (n = 97) methamphetamine. Measures included the Timeline Followback, Severity of Dependence Scale, Amphetamine Withdrawal Questionnaire, Craving Experience Questionnaire and the Brief Psychiatric Rating Scale (symptoms of depression, hostility, psychosis and suicidality). Simultaneous regression was used to identify independent demographic correlates of smoking methamphetamine and to compare the clinical characteristics of participants who smoked versus injected. Results: Compared to participants who injected methamphetamine,

N-acetylcysteine (NAC) for methamphetamine dependence: A randomised co by Rebecca McKetin, Olivia M Dean et al

N-acetylcysteine (NAC) for methamphetamine dependence: A randomised co by Rebecca McKetin, Olivia M Dean et al
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